CDc25 phosphatase

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CDc25 phosphatase

A group of intracellular enzymes that regulate cell division, some of which may contribute to the conversion of normal cells to cancer cells.
See also: phosphatase
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Catalytic and chemical competence of regulation of cdc25 phosphatase by oxidation/reduction.
In mammals, there are three isoforms of CDC25, CDC25A, CDC25B, and CDC25C (9).
Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption.
Flt3-ITD mutated leukemic cells have enhanced activity of Cdc25, which overrides the replication checkpoint leading to arrest in the S phase [45].
Garbay, "Rapid discovery of triazolobenzylidene-thiazolopyrimidines (TBTP) as CDC25 phosphatase inhibitors by parallel click chemistry and in situ screening," Journal of Combinatorial Chemistry, vol.
Li et al., "Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2," Cell Stress & Chaperones, vol.
After DNA damage, ATR/ATM made CHK1 and CHK2 acquire kinase activity and then phosphorylated the downstream CDC25 family and other substrates.
USP8 was originally identified to enhance cell growth as its expression increases upon serum stimulation in cancer cells.[sup][17] In addition, it has been reported that USP8 interacts with a number of clinically relevant cancer targets including Cdc25,[sup][18] Erbb2,[sup][19] EGFR,[sup][20] and Nrdp1[sup][21] and implying a crucial role of USP8 in cancers.
A similar example in Ciona embryos is suppression of Cdc25 activity in neural tube cells during neural tube closure; in this process, the Cdc25 gene may be regulated transcriptionally.
According to the resolved structure of the ras-SOS complex (PDB ID: 1BKD) [35], the CDC25 binding region is tightly bound to the Switch II of ras and causes the disruption of the GDP bound structure [35].
Accordingly, partial inactivation of PKA catalytic subunits, cAMP synthesis, or regulatory proteins of the pathway (e.g., Cdc35/Cyr1, Cdc25, Gpr1, and Gpa2 in yeast) are frequently used as calorie restriction mimetics and mitigate aging and/or age-related diseases in mice [9, 81, 82], Drosophila [83], and yeast ([4, 84], Figure 1(b)).
Furthermore, an important potential target of miR-503 is the cell cycle regulator CDC25.