CDC20

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CDC20

A gene on chromosome 1p34.1 that encodes a regulatory protein which interacts with other proteins at multiple points in the cell cycle. CDC20 is required for two microtubule-dependent processes: nuclear movement prior to anaphase and chromosome separation. CDC20 is required for full ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. It is regulated by MAD2L1.
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dA/dt = [V.sub.synthesis] - ([K.sub.0] * A + [K.sub.1] * Cdc20a * A/[K.sub.M1] + A).
dA/dt = 0; you can know when Cdc20a (it is cell cycle regulator) = 0 that we get the maximum A = [V.sub.synthesis]/[K.sub.0].
Time constant T = 1/((([K.sub.1] * Cdc20a)/[K.sub.M1])+[K.sub.0]) mainly affected by ([K.sub.1] *Cdc20a)/[K.sub.M1].
[V.sub.m1b] is the internal synthesis rate of protein Cdc20a; [V.sub.2] is its degradation rate of protein Cdc20a; [k.sub.1b] and [k.sub.2b] are protein Cdc20a's modifier coefficients.)