CD99

CD99

a type I transmembrane protein present on thymocytes, lymphocytes, and myeloid cells involved in rosette formations with sheep erythrocytes.
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CD99 was performed on 19 cases and showed characteristic dot like staining.
Mucosal melanoma is usually positive for S100, HMB-45, Melan-A, and melanogenesis-associated transcription factor (MITF), and negative for cytokeratins, CD99, desmin, myogenin, and CD45.
Immunohistochemically, the tumor cells were positive for vimentin, sex determining region of Y chromosome-related high-mobility group box gene-9 (SOX-9), S-100, P16, murine double minute 2 (MDM2), and cyclin-dependent kinase 4 (CDK4) and negative for pan-cytokeratin (PCK), epithelial membrane antigen (EMA), smooth muscle actin (SMA), desmin, myogenin, cluster of differentiation 10 (CD10), CD31, CD34, caldesmon, CD99, beta-catenin, signal transducer, and activator of transcription 6 (STAT-6).
It was consistent with PNET being positive for vimentin, CD99 and FLI-1 (friend leukaemia integration-1) and negative for desmin, mesothelin and cytokeratin.
Sonrasinda patolojik tani icin yapilan osteocut ile kemik biyopsisinden elde edilen materyalin immunohistokimyasal incelenmesinde CD 45, EMA, Tdt, S-100, Pan-CK, Myogenin tumor markerlari negatif gelirken Ewing sarkomu icin spesifik olan Vimentin ve CD99 pozitif olarak saptandi.
The mass was negative for CD99, cytokeratin, smooth muscle actin, muscle-specific actin, S100, desmin, LCA, CD3, CD20, CD31, and myoglobin.
Additionally these lesions usually stain for CD34, desmin, BCL2, CD99, CD10 and WT1.
Immunohistochemistry showed strong membranous positivity with CD99 and some positivity with CD56 and synaptophysin.
Immunohistochemistry: Collagen type IV, vimentin, nuclear MDM2 positivity, BCL-2, CD99, CD34 focal positivity.
However, CD99 immunostain positivity plays its utmost diagnostic role in these tumors.
All other tested markers (TCA, CD3, CD79a, chromogranin A, synaptophysin, myogenin, desmin, S-100 protein, TdT, LMP1, CD99, TTF-1 and CK-14) were negative, except for a weak expression of neuron-specific enolase (NSE).
These molecules include platelet/EC adhesion molecule-1 (PECAM-1), CD99, junctional adhesion molecules A and C (JAM-A and JAM-C), and JAM-like protein (JAML) [79].