CD95


Also found in: Dictionary, Thesaurus, Financial, Encyclopedia.
Related to CD95: Fas protein, Fas ligand

CD95

a type I transmembrane protein present on T cells and myeloid cells that may induce apoptosis.

FAS

A gene on chromosome 10q24.1 that encodes a member of the TNF-receptor superfamily which is a receptor for TNFSF6/FASLG. FAS contains a so-called death domain, and plays a central role in regulating apoptosis. Ligand binding to FAS results in the formation of a death-inducing signalling complex, comprised of Fas-associated death domain protein (FADD), caspase 8 and caspase 10.

Molecular pathology
FAS has been implicated in the pathogenesis of cancer and immune diseases.
Mentioned in ?
References in periodicals archive ?
Briefly, the slides were incubated at 37C for 60min with the following primary antibodies (all from Neomarkers, Thermo Fisher Scientific): CD95 (Ab-3 Clone GM30, 1:30 dilution), anti-COX-2 (RB-9072-PO, 1:40 dilution).
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
Expression on the membrane structures by the superficial CD95 molecules (sFas and sFasL) potentiates cells' readiness to introduction to apoptosis as direct interaction of them with these ligands is one of the leading mechanisms of launching of apoptosis.
Other triggered mechanisms by MTX are inhibition of T cell activation and suppression of intercellular adhesion molecule expression by T cells, increasing CD95 sensitivity of activated T cells, and inhibition of methyltransferase activity, leading to (de)activation of enzyme activity relevant to immune system function [22].
Overexpression of MARCH8 leads to the downregulation of several immunomodulatory receptors, including MHC I HLA 2.1, MHC II, CD95 (Fas), B7.2, TfR, CD166, CD44, CD88, and CD98, indicating that it plays a significant role in immune suppression [6, 15, 30, 31, 37, 46, 95, 96].
Kayagaki et al., "Serum levels of soluble Fas/APO-1 (CD95) and its molecular structure in patients with systemic lupus erythematosus (SLE) and other autoimmune diseases," Clinical and Experimental Immunology, vol.
While the extrinsic apoptotic pathway is initiated by the activation of Fas (CD95) and tumor necrosis factor [alpha] receptors and their respective ligands, the intrinsic pathway is initiated by apoptotic stresses, such as p53, and ultimately results in disruption of the mitochondrial membrane and leakage of cytochrome-c into cell cytoplasm.
The scientists believe that possessing an abnormal version of the CD95 gene - involved in controlling cell death in the body - may also dictate survival rates for other types of cancer, including lymphoma, breast cancer and prostate cancer.
The scientists believe that possessing an abnormal version of the CD95 gene - involved in controlling cell death in the body - may also affect survival rates for other types of cancer, including lymphoma, breast cancer and prostate cancer.
Analisis de la expresion ex vivo de FAS (CD95), HLA-DR e IL-7R0C (CD127)
Despues de la activacion de las celulas T y del control del antigeno que desencadeno la respuesta inmune, se activa la via apical de muerte celular por la union del ligando Fas (FasL, CD95L) con su receptor de superficie (CD95) (61).
Dr Ateh and his colleagues found that by coating tiny microparticles of around a hundredth the diameter of a human hair with a special protein called CD95, they could in fact trigger cancer cells into ingesting these particles.