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Related to CD95: Fas protein, Fas ligand


a type I transmembrane protein present on T cells and myeloid cells that may induce apoptosis.


A gene on chromosome 10q24.1 that encodes a member of the TNF-receptor superfamily which is a receptor for TNFSF6/FASLG. FAS contains a so-called death domain, and plays a central role in regulating apoptosis. Ligand binding to FAS results in the formation of a death-inducing signalling complex, comprised of Fas-associated death domain protein (FADD), caspase 8 and caspase 10.

Molecular pathology
FAS has been implicated in the pathogenesis of cancer and immune diseases.
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The team studied the role of CD95 in tumours using several human cancer cell lines, liver cancer mouse models, and models of ovarian cancer.
About APG101 Apogenix' lead immuno-oncology candidate APG101 is a fully human fusion protein that consists of the extracellular domain of the CD95 receptor and the Fc domain of an IgG antibody.
Decreased CD95 expression on naive T cells from HIV-infected persons undergoing highly active anti-retroviral therapy (HAART) and the influence of IL-2 low dose administration, khan Study Group.
Lack ofT-cell receptor-induced signaling is crucial for CD95 ligand up-regulation and protects cutaneous T-cell lymphoma cells from activation-induced cell death.
About APG101 Apogenix' lead drug candidate APG101 is a fully human fusion protein that consists of the extracellular domain of the CD95 receptor and the Fc portion of an IgG antibody.
CD3, CD4, CD9, CD11, CD19, CD20, CD22, CD26, CD27, CD28, CD29, CD33, CD37, CD40, CD44, CD45, CD47, CD52u CD55, CD56, CD66, CD70, CD74, CD80, CD95, CD98, CD100, CD117, CD135, CD137, CD152, CD200, CD223, CD227, CD246, CD248, CD274, CD276, CD279
TEHRAN (FNA)- Cancer cells - and not normal cells - can be killed by eliminating either the FAS receptor, also known as CD95, or its binding component, CD95 ligand, scientists demonstrated.
Quotations are invited for Supply of Antibodies, Human CD44 APC G44-26 Pack size: 100 tests, Human CD95 PerCP-Cy5.
The Newcastle researchers found that patients with the risk version of the CD95 gene had a better chance of survival if they were given an increased dose of ATRA alongside their chemotherapy.
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation ofc FLIP(short).
Indeed, the lack of CD95 marker is sufficient to identify a population of naive T cells, as defined by coincidence with previously characterized CD45RA (+) CD62L (+) T cells.