Changes in endometrial natural killer cell expression of CD94
, CD158a and CD158b are associated with infertility.
Increase of CD69, CD161 and CD94
on NK cells in women with recurrent spontaneous abortion and in vitro fertilization failure.
Hepatosplenic T-cell lymphoma shows phenotypic aberrancy through frequent loss of CD5 and/or CD7, as well as reactivity with multiple killer immunoglobulin-like receptors and a weak to negative reaction to CD94
CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94
1A transcripts characterize lymphoblastic lymphoma/ leukemia of immature natural killer cell origin with distinct clinical features.
Some studies suggest that expression of NK cells triggering receptors, including CD94
, KIR (CD158a/h and CD158b/j), NKp46, and NKG2D, does not differ between CB and APB NK cells, while others reported that a higher percentage of CB NK cells express the inhibitory receptor complex of CD94
/ NKG2A and CD158b/j (38), (39).
Lo mismo ha ocurrido en LNH en humanos, donde se atribuye que el origen de este tipo de linfomas es a partir de celulas naturales asesinas (NK); para su confirmacion, seria necesario utilizar otros anticuerpos especificos para antigenos de membrana de esas celulas, que en humanos son CD56, CD94
y CD16 (Abbas et al.
Examples of other C-type lectin-like receptors that occur as individual genes are CD94
, CD69 and AICL.
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Las celulas NKT (Natural killer T) expresan TCR con un limitado repertorio (V[alfa]24J[alfa]Q y V[beta]11) y receptores de celulas NK tipo lectina como CD94
y CD161, que les permiten reconocer glicolipidos endogenos presentados por las moleculas CD1.
Cytotoxic markers (TIA-1, Granzyme B, and By55) and NK marker CD94
strongly stained neoplastic cells (Figure, c).
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