The human Fc receptor for IgA (Fc alpha RI, CD89
) on transgenic peritoneal macrophages triggers - phagocytosis and tumor cell lysis.
The flow cytometric analysis of their phenotypic markers showed that BM-MSCs of AA patients as well as of controls expressed comparable levels of MSC markers CD73, CD89
, CD105, and CD166 and lacked the expression of CD13, CD34, CD45, and HLA-DR (Figure 1(a)).
Progenitor [feminidad] Progenitor [masculinidad] [F.sup.1] GRO-08 Freedom red MOR-6 Prestige CD1 MEX-08 Freedom red GRO-4 Prestige CD19 MOR-01 Festival red GRO-7 Prestige CD34 MOR-05 Freedom red GRO-7 Prestige CD42 MOR-21 Freedom red GRO-11 Prestige CD47 MOR-21 Freedom red OAX-10 Prestige CD50 NAY-13 Freedom red GRO-11 Prestige CD70 PUE-07 Freedom red GRO-7 Prestige CD81 SIN-02 Freedom red GRO-7 Prestige CD89
[F.sub.1] Designacion de la cruza, GRO: Guerrero, MEX: Mexico, MOR: Morelos, NAY: Nayarit, PUE: Puebla, SIN: Sinaloa, OAX: Oaxaca.
) is a receptor for IgA and plays important roles in immune responses, and it is expressed constitutively on monocytes, macrophages, eosinophils, neutrophils, and some types of dendritic cells.
Hypogalactosylated IgA molecules evoke the synthesis of IgG autoantibodies that form circulating immune complexes that end up entrapped in the mesangial area due to interactions between CD89
and mesangial cell receptors like CD71.
Van De Winkel, "Effective phagocytosis and killing of Candida albicans via targeting Fc[gamma]/RI (CD64) or Fc[alpha]RI (CD89
) on neutrophils," Journal of Infectious Diseases, vol.
Based upon their functional involvement, several genes like core-1-b, 3-galactosyltransferase (C1GALT1) and its specific molecular chaperone b1, 3-GT (C1GALT1C1) GalNAc a2, 6-sialyltransferase (ST6GALNAC2) transferrin receptor (TFRC) immunoglobulin A, Fca receptor (CD89
) and toll like receptor 4 (TLR4) become promising candidate genes for IgAN.
They found that insulin increased the total number of neutrophils and the number of these expressing CD11b, CD15, CD62L, and CD89
, whereas the density of these molecules was downregulated.
van Egmond, "The Fc receptor for IgA (FcaRI, CD89
)," Immunology Letters, vol.
Monteiro, "Colostral neutrophils express Fc[alpha] receptors (CD89
) lacking y chain association and mediate noninflammatory properties of secretory IgA," Journal of Leukocyte Biology, vol.
constructed a bispecific antibody with the ability to interact with HIV and HIV-infected cells in one direction and with CD89
in the other.