CD151 and CD83
have critical roles in CD4 T cell activation.
Triple costimulation via CD80, 4-1BB, and CD83
ligand elicits the long-term growth of V[gamma]9V[delta]2 T cells in low levels of IL-2.
Chen et al., "Expression and distribution of S-100, CD83
, and costimulatory molecules (CD80 and CD86) in tissues of thyroid papillary carcinoma," Cancer Investigation, vol.
Another study directly showed that Mtb induced monocyte-derived human DC maturation through increasing the expression of CD80, CD86, CD40, CD83
, HLA-DR, and HLA-I, as well as cytokine production including IL23.
CCR7 is induced together with the maturation of DCs, which was characterized by the upregulated expression of MHC molecules and costimulatory molecules such as CD80, CD83
, and CD86, as well as CCR7 [32, 33], and is essential for DC mobilization.
Recent studies demonstrated that MSCs have immunosuppressive functions on DCs in the form of restraining DC differentiation from monocytes and decreasing the cell-surface expression of CD1-[alpha], CD40, CD80, CD83
, CD86, and MHCII .
Cell surface expression of CD83
, CD80, MHCII, and other costimulators significantly increases upon DCs maturation .
Decreasing expression of CD80, CD83
, CD86, and major histocompatibility complex (MHC) II on the surface of DCs can inhibit the proliferative effects on T cells.
Cada una de las poblaciones se evaluaron para la expresion de CD14: HLADR y la coexpresion de CD83
y CD86, por citometria de flujo.
cDNA was amplified by PCR using the following primer kits: [RT.sup.2] qPCR Primer Assay for human CD83
and as housekeeping genes [RT.sup.2] qPCR Primer Assay for human GAPDH and HPRT.