Wu et al., "Anti-miR-362-3p inhibits migration and invasion of human gastric cancer cells by its target CD82
," Digestive Diseases and Sciences, vol.
Since exosomes originate in the endosome, some endosomal-associated proteins are ubiquitously present in exosomes, including membrane transport and fusion-associated proteins (Rab-GTPase, annexin, and heat shock proteins (HSPs), including Hsp60, Hsp70, and Hsp90), four-transmembrane cross-linking proteins (tetraspanins) (including CD9, CD63, CD81, and CD82
) and MVB-related proteins (Alix and TSG101) (widely used for the identification of exosomes [4, 20]).
miR-362-3p targeted by CD82
induced tumor formation, affected epithelial-mesenchymal transition (EMT) processes, and promoted the migration and invasion of gastric cancer cells .
Members of tetraspanins, CD82
and CD63, members of integrin's family LFA-1, integrin [beta]1, CD11b, and integrin [alpha]v[beta]6, and members of Ig superfamily ICAM-1 and CD48 also show interaction of EBV glycoproteins and CD21 .
Tu et al., "Nuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82
in gastric cancer," Cell Death and Disease, vol.
HIF-2 directly activates CD82
gene expression in endothelial cells.
The gene profiling analysis revealed the modulation of several genes including cytokines (e.g., IL-1[alpha], IL-1[beta], IL-6, TNF-[alpha], IFN-[beta]1 and G-CSF), chemokines (e.g., CCL3, CCL4, CCRL2, CXCL2 and CXCL10), as well as several co-stimulatory molecules (e.g., CD14, CD40, CD69, CD82
, CD83 and CD274).
The CD73 can be upgraded to the CD82
or the CD192 by the factory at any time.
reported the increased expressions of TSG-6 as well as STC1 and three anticancer proteins, TRIL, IL-24 and CD82
, from MSCs when they are grown in 3D spheroids .
If this first IHC panel is inconclusive, additional markers, such as CD82
, claudin 7, and claudin 8, can be used.
Trojanowicz et al., "CD82
, and CD63 in thyroid cancer," International Journal of Molecular Medicine, vol.
MSCs cultured as 3D spheroids also exhibited an increased level of certain proteins and cytokines with more than purely immunomodulatory effects, such as antioncogenic proteins IL-24, TNF-[alpha], CD82
, vasculogenesis and angiogenesis promoter VEGF, and proteins involved in cell differentiation and survival such as TGF-[beta]3 [82, 83].