CD81

CD81

a type III transmembrane protein present on many cell types, including lymphocytes, which facilitates signal transduction; expressed on lymphomas, leukemias, melanomas, and neuroblastomas.
Mentioned in ?
References in periodicals archive ?
NTA revealed that the ADSC-derived exosomes appeared as nanoparticles (40-200 nm), and Western blotting confirmed positive expression of CD9, CD81, flotillin-1, and HSP70 versus ADSC cytoplasmic proteins (all P < 0.
Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I.
Tetraspanins CD9 and CD81 are molecular partners of trimeric FcsRI on human antigen-presenting cells.
In addition, SLL is negative for CD10, CD81, and FMC-7, and negative to dimly positive for CD79b.
El hibrido CD70 sobresalio por su grosor de tallo y fue el de valor mas alto con 24,62mm en promedio, pero fue similar a CD42 y CD50, El de menor diametro fue CD81 con 16,72mm, Con base en la expresion fenotipica del grosor de tallo, aspecto fundamental en soporte de la planta, existen materiales promisorios con el acervo genetico para este caracter, el cual se le dara mayor enfasis en las generaciones siguientes, mediante la propagacion clonal para mantener la identidad genetica (Islam et al.
Las proteinas de envoltura E1 y E2 juegan un papel importante en el tropismo viral y la entrada al hepatocito, a traves de la union a sus receptores SR-B1, CD81, Claudina y Occludina (32) y son inmunogenos potentes, evidenciado por el hecho de activar respuesta de memoria, caracterizada por la presencia de linfocitos B de memoria inducidos por la proteina E2 identificado en mas del 90% de los individuos evaluados, lo que se correlaciona con la presencia de anticuerpos especificos contra E2 (33).
Because of their endosomal origin, all exosomes contain membrane transport and fusion proteins (GTPases, annexins, and flotillin), tetraspanins (CD9, CD63, CD81, and CD82), heat shock proteins (Hsp70 and Hsp90), proteins involved in multivesicular biogenesis (Alix and TSG), and lipid-related proteins and phospholipases [7, 8].
18 gene specific primers (TLR2, NFKB1, IL2, IL16, TNF, IFNG, CXCR3, CCL1, CD81, CD84, RPS6KB2, STK17B, PRKCB1, MCL1, EEF1G, NFATC4, EEF1 and IER5) were used for real time expression profiling (24) (Table 1).
Numerous molecules can serve as HCV receptors, such as scavenger receptor class B type I, low-density lipoprotein receptors, CD81, claudin-1, occludin, epidermal growth factor receptor, and Niemann-Pick C1-like 1 cholesterol absorption receptor (for a review, see Lindenbach and Rice 2013).
6) CD81 has been identified as a critical co-receptor for HCV particle entry.
This molecule acts as B cell co-receptor in association with other surface B cell receptors including CD21, CD81 and CD225, and modulates signaling thresholds of BCR activation (8-10).
This is supported by experiments showing that hepatic CD81 expression is increased in Pcsk9 (KO) mice and PCSK9 downregulates CD81 independently of LDL-R.