CD8 cell


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CD8 cell

A suppressor T cell, e.g., a cytotoxic T cell.
See also: cell
References in periodicals archive ?
A small case-control study determined that aging HIV-infected people (median 56 years) with a good CD4 count (median 724 cells/mm (3)) and long-term viral suppression with antiretroviral therapy have CD4 and CD8 cells similar to those of a substantially older HIV-negative comparison group (median 88 years) and utterly unlike those of a younger HIV-negative group (median 27 years).
In the body, CD8 cells can transform themselves into killers that seek out and destroy other cells infected by HIV.
Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts.
Low densities of peritumoral infiltrates of CD3 and CD8 cells or lowered ratios of CD8/Tregs have been reported to be useful predictive markers of progressive disease in cervical and colorectal cancers (34,58).
Initially, the researchers identified CD8 cells, which are involved in the autoimmune process and are supposedly responsible for destroying CD4 cells in the immune system.
Patients in the CBSM group also showed significant decreases in certain types of CD8 cells.
Other cells of the immune system, CD8 cells, usually fail to defend against the virus.
Through various tests, they found that these chemicals were produced by stimulated CD8 cells of three of the long-term non-progressors they are studying (they picked their three best non-progressors among their patients, in order to have the best chance of identifying how their cells are able to keep HIV in check).
All 60 of those studied had CD8 cells in their bodies.
CD4 immune cells attack disease-causing intruders, while CD8 cells suppress the attack.
Many potential vaccines stimulate an antibody response but not the CD4 and CD8 cells necessary for full protection from disease, says Beltz.
In a separate study, they reported that relative abundance in tumors of a partially exhausted T-cell phenotype ([PD-1.sup.high]/CTLA-4-positive CD8 cells) was predictive of response to anti-PD-1 therapy.