TAT2 (GRN 163L), a small-molecule telomerase activator, "modestly" retarded telomere shortening while enhancing antiviral activity of CD8 cells
collected from people with HIV.
Gallo of the University of Maryland's Institute of Human Virology in Baltimore and his colleagues report that when CD8 cells
are stimulated out of their quiescent state, as they would be when responding to an infection, they make CD4.
But in a small group of HIV-infected people known as long-term nonprogressors, those CD8 cells
seem to stave off the development of AIDS, even in the absence of anti-HIV drugs.
But in the US study, the CD8 cells
suppressed the virus without killing the healthy CD4T cells.
Overall, they found that the telomere length of CD8 cells
was significantly shorter than CD4 telomere length in a group of 14 HIV-infected men, suggesting the new CD8 cells
were being produced much faster than CD4 cells.
CD4 immune cells attack disease-causing intruders, while CD8 cells
suppress the attack.
Many potential vaccines stimulate an antibody response but not the CD4 and CD8 cells
necessary for full protection from disease, says Beltz.
Specifically, rhIL-7 blocks sepsis-induced depletion of CD4 and CD8 cells
, enhances lymphocyte recruitment, prevents the sepsis-induced loss in immunity as evidenced by preserved delayed-type hypersensitivity response, does not exacerbate the proinflammatory response in sepsis, and clearly improves survival.
high]/CTLA-4-positive CD8 cells
as compared with men (mean, 16.
We will examine the effect of triggering innate responses in DC using HIV-1 mutants/drug treated wild type virus on allogeneic responses, by measurement of T cell proliferation and function and in an ex vivo CD8 T cell killing assays using peripheral blood CD8 cells
from HIV-1 infected patients.
After the infusion, the CD8 cells
in the infected mice revived and the levels of virus in their bodies decreased by a factor of four after a month.
By looking at the numbers of CD4 and CD8 cells
, checking the ratio between them and measuring the cytokine production, one can tell if a patient has HIV in only a few seconds.