TAT2 (GRN 163L), a small-molecule telomerase activator, "modestly" retarded telomere shortening while enhancing antiviral activity of CD8 cells
collected from people with HIV.
Since CD8 cells
weren't known to make CD4, a prerequisite for infection by the virus, the puzzling results went unexplained and to some extent ignored.
a subset of T cells that help regulate and carry out the body's immune response HIV human immunodeficiency virus retrovirus any of a family of RNA viruses that modify the genetic structure of host cells by re-creating themselves viral load amount of virus that you can determine to be present in blood or other tissues -0- 1/26/96
The ability of subjects treated in Cohort 3* to suppress and sustain control of viral load, combined with durable increases in CD4 and CD8 cells
, provide support for our hypothesis of an immunologic mechanism of action for SB-728," said Dale Ando, M.
When we depleted their CD8 cells
, the infected monkeys developed disease closely mirroring that of human patients.
CD4 cells can be more efficient at tumor rejection than CD8 cells
The engineered stem cells developed into a large population of mature, multi-functional HIV-specific CD8 cells
that could specifically target cells containing HIV proteins.
They showed that looking at CD38 (mean fluorescence intensity) on memory type CD8 cells
(CD45 RO+) improved the performance of their assay giving a receiver operator characteristics area under curve (AUC) of 0.
This may be of relevance in the natural history of HPV infection and cervical cancer since Tregs may be exerting a "dominant" form of immunotolerance on many different cell types such as NK and CD8 cells
Offering classical and new techniques, they also cover a number of disciplines as they address the molecular mechanisms of allergy, culture of T-cells from peripheral blood, T-cell lines and human T-cell clones, human T-cell epitopes of allergens, restriction of T-cell responses, short-term culture of CD8 cells
and intracellular cytokine staining, processing of certain T-regulatory cells, using monocyte-derives dentritic cells and antigen-presenters in T-cell proliferation and cytokine production, human cytokine responses, human chemokine production, standardization and characterization of allergen extracts, conjugation of haptens, monoclonal antibodies, air sample assays, hologene assays, microscopic identification of pollens, identification of mast cells, and in-situ hybridization.
T cell: A disease-fighting white blood cell, including CD4 and CD8 cells
Patients in the CBSM group also showed significant decreases in certain types of CD8 cells