CD8 antigen

CD8 antigen

A glycoprotein cell surface molecule on cytotoxic T cells (T LYMPHOCYTES) that recognizes major histocompatibility complex (MHC) class I molecules on target cells. Because of this, cytotoxic T cells are often referred to as CD8 cells.
References in periodicals archive ?
a monoclonal antibody to the human cd8 antigen conjugated to pacific blue / bv421 / alexa 405
Binding of the FITC-labelled antibodies against CD4 and CD8 is not reduced by increasing concentrations of AGP, indicating lacking competition of AGP with the antibodies for the same epitopes on CD4 and CD8 antigen.
10,12] In one report of B-CLL, CD8 expression on B cells was suggested as a marker of aggressive disease[6]; however, other reports did not show any difference in presentation or survival of these patients when compared with patients with classic B-CLL, strongly suggesting that CD8 antigen is not a marker of aggressive disease.
Aberrant CD8 antigen expression in a patient with chronic lymphocytic leukaemia showing unusual disease progression.
B-cell chronic lymphocytic leukemia with CD8 expression: report of 10 cases and immunochemical analysis of the CD8 antigen.
B-cell chronic lymphocytic leukaemia with aberrant expression of CD8 antigen.