female genital tissue) where the infection might start, so that the immune system can generate these CD8 T-cells, travel back to the vaccination site and eliminate any future virus that is encountered.
Now the researchers have found that their vaccination strategy marshals a platoon of immune cells, called innate lymphoid cells (ILC1) and monocytes, in the genital tissues to work together and release chemicals (chemokines) to send out a call to the CD8 T-cells generated by the vaccine to troop into the genital tissue.
Shaffer et al., "mTOR regulates memory CD8 T-cell
differentiation," Nature, vol.
Our studies  and others [67-69] have shown that [Tc.sub.REG] are regulated by induction locally (e.g., in the bone marrow) from naive CD8 T-cells; hence, their steady state abundance would be low in lymphoid tissue.
Aurora, "[FoxP3.sup.+] CD8 T-cells can suppress bone turnover in response to RANKL administration and in ovariectomized mice," Bone.
First, they exposed the CD8 T-cells from HIV-infected persons to TAT2 to see if the chemical not only slowed the shortening of the telomeres but also improved the cells'' production of soluble factors called chemokines and cytokines, which had been previously shown to inhibit HIV replication.
They then took blood samples from HIV-infected individuals and separated out the CD8 T-cells and the CD4 T-cells - those infected with HIV.
The consistent activation of CD4 and CD8 T-cells
is associated with depletion of CD4 T-cells and increased risk of disease progression to AIDS .