cytotoxic T cell

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cytotoxic T cell

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
(4) Similarly, chronic consumption of 18 percent ethanol in water for 31 weeks resulted in impaired antigen-specific CD8 T-cell responses following inoculation with Listeria monocytogenes (Gurung et al.
Kennedy et al., "The level of viral antigen presented by hepatocytes influences CD8 T-cell function," Journal of Virology, vol.
Later on--anywhere from 14-75 years after vaccination--many individuals still maintained both CD4 and CD8 T-cell memory, although at lower levels than before.
* Why are peripheral blood CD4 T-cell counts more affected than peripheral blood CD8 T-cell counts?
"At early time points ranging from 27 days to 7 years after vaccination, nearly all volunteers possessed strong CD4 and CD8 T-cell responses." Later on--14-75 years after vaccination--many individuals maintained both CD4 and CD8 T-cell memory, although at lower levels than before.
Engelhard, "Chapter Eight --control of CD8 T-cell infiltration into tumors by vasculature and microenvironment," Advances in Cancer Research, vol.
Shaffer et al., "mTOR regulates memory CD8 T-cell differentiation," Nature, vol.
The proprietary system allows the secretion of the antigen together with an immunological adjuvant which has been demonstrated to be required for optimal induction of CD8 T-cell responses by recombinant Salmonella based bacterial vaccines.
Immunohistochemistry analyses of lesional skin biopsy specimens from treated patients showed a significant increase in the numbers of infiltrating CD8 T-cell subset markers and T-cell intracytoplasmic antigen-1 cytolytic granule markers.
Schluns, "Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation," Blood, vol.
The latter appeared to be better suited to interrogate the CD4 as well as the CD8 T-cell compartment in a ROC analysis, and associated a higher pp65-specific CD4 T-cell response with protection from CMV replication.
In order to identify minimal sets of epitopes (optimal epitope combinations) with a target PPC within a starting set of CD8 T-cell epitopes, we first find the HLA I molecules that could present those epitopes by predicting their binding to 55 HLA I molecules (HLA I binding profile), as indicated elsewhere in Section 2.