This non-exclusive collaboration agreement builds on a previous one between Innate Pharma and AstraZeneca -- an ongoing co-development and commercialisation agreement for monalizumab, a first-in-class humanised IgG4 targeting NKG2A receptors expressed on tumour infiltrating cytotoxic NK and CD8 T lymphocytes
Cytotoxic CD8 T lymphocytes are responsible for elimination of different intracellular infections.
According to our data an increase of relative number of CD8 T lymphocytes in HIV infected patients at all stages of the infection was observed.
In humans, numerous studies have established the favorable prognosis associated with an infiltration of primary tumors by abundant memory T lymphocytes, particularly CD8 T lymphocytes.
The former are recognized by CD8 T lymphocytes with cytolytic capacity and the latter by CD4 T lymphocytes capable of multiple immunoregulatory functions.
Laboratory control values for CD4 and CD8 T lymphocytes.
Enumeration of CD4 and CD8 T lymphocytes in healthy HIV seronegative adults of northwest India: a preliminary study.
CD38 expression on CD8 T lymphocytes
as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy.
Altered expression of survival (CD 127) and death (Pas) receptors in total, naive and memory CD8 T lymphocytes
from Human Immunodeficiency Virus infected patients: possible implications for progression of infection.
Also see Evans 2002 (3): "Our findings provide the first evidence that depression may alter the function of killer lymphocytes in HIV-infected women and suggest that depression may decrease natural killer cell activity and lead to an increase in activated CD8 T lymphocytes
and viral load" (quote from the abstract).
Ho's group found that these survivors exhibited revved-up activity of white cells called CD8 T lymphocytes
22] This anti-HIV activity includes suppression of HIV replication mediated by a soluble antiviral factor produced by activated CD8 T lymphocytes