The binding between TCR on CD8 T cells
and peptide/ MHC complexes on APC leads to T cell proliferation and differentiation.
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells
that give rise to long-lived memory cells.
In resource-limited settings this could provide a means of limiting cost by reducing expensive viral load testing, however, there is insufficient data to support the use of CD8 T cell
activation measures to detect virological failures under HAART.
These new assays were based on measuring antigen-specific cytokine production in both CD4 and CD8 T cells
from HIV-infected people.
As expected, CD8 T cells
produced large amounts of these enzymes upon stimulation with PMA/ionomycin.
Using the activation markers CD38 and HLA-DR, they showed that there is a large and significant difference between the T cell activation (both CD4 and CD8 T cells
) of patients who become undetectable on ART compared to patients before they start treatment and to those on treatment who do not achieve an undetectable viral load.
Studies in rhesus monkeys have shown that significant and persistent virus-specific T cell responses can be elicited with vaccines incorporating viral genetic sequences and that these responses are primarily mediated by CD8 T cells
. Benefits such as stable CD4 levels and viral control have resulted.
Murali-Krishna et al., "Rapid demethylation of the IFN-[gamma] gene occurs in memory but not naive CD8 T cells
," The Journal of Immunology, vol.
Generation of genome-wide CD8 T cell
responses in HLA-A*0201 transgenic mice by an HIV-1 ubiquitin expression library immunization vaccine.
In every participant, the vaccine engendered antibodies against circumsporozoite and whipped up an army of immune system warriors called CD4 and CD8 T cells
, says study coauthor Giampietro Corradin, a biochemist at the University of Lausanne in Epalinges, Switzerland.
van den Broek, "Resting dendritic cells induce peripheral CD8 T cell
tolerance through PD-1 and CTLA-4," Nature Immunology, vol.
CD4 T cell count was 410 cells/[mm.sup.3] and CD8 T cell
count was 940 cells/[mm.sup.3].