Professor Lalvani said that the immune system produces these
CD8 T cells in response to usual seasonal flu.
This study reports T cell activation defined by CD38 and HLA-DR with quantitative assessment of CD38 and compares these measures of immune activation with serological markers, and uses proportional hazards modelling to demonstrate that
CD8 T cell activation defined by CD38 expression was the strongest predictor of clinical progression [4].
These new assays were based on measuring antigen-specific cytokine production in both CD4 and
CD8 T cells from HIV-infected people.
As in the study reviewed here, this development and expansion of CD4 and
CD8 T cells appears to result in an immune system recovery which may be associated with a lower incidence of opportunistic infections and a longer life expectancy, a clinical benefit that we hope to demonstrate in future large-scale randomized clinical studies.
CD38 expression on
CD8 T cells with or without other markers (HLA DR and CD45RA) is not adequate to predict the virological response to antiretroviral therapy (ART) in Ugandans: XVI International AIDS Conference Toronto (Abstr.
Evaluate whether any observed changes in CD4 and
CD8 T cell counts are due to increasing thymic output and/or peripheral T cell expansion
After 48 weeks, patients treated at the higher dose level showed a median increase in CD4 and
CD8 T cell counts (cells/microliters) of 75% and 58%, respectively, from baseline levels.
The study data also showed enhanced HIV-specific CD4 and
CD8 T cell activity in these patients.
The vaccine is aimed at inducing strong and persistent HIV-1 gag specific
CD8 T Cell responses.
One study revealed mostly similar distributions of CD4 and
CD8 T cell subsets in LTNPs and patients in the early phase of infection (Clin Diagn Lab Immunol, 5:5, p.
Researchers in France compared
CD8 T cell responses from 24 patients with documented PHI to CD8 responses from 30 asymptomatic HIV-infected patients who were antiretroviral treatment naive (Abstract 573).
This new study follows positive results from a recently completed study conducted by NIH in collaboration with Kaleidos Pharma demonstrating that TGF alpha increased both CD4 and
CD8 T cell counts in SIV-infected monkeys.
