cytotoxic T cell

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Related to CD8 T cell: CD4 T cells, Memory T cells

cytotoxic T cell

cytotoxic T cell

See CD8 cell.

cytotoxic T cell

A CD8+ T lymphocyte that can destroy microorganisms directly through the release of perforin and proteolytic enzymes. These cells are particularly important in the defense against viruses, rejection of allografts, and, possibly, new malignant cells. Synonym: CD8 cell; cytotoxic cel; killer T cell
See also: cell
References in periodicals archive ?
In resource-limited settings this could provide a means of limiting cost by reducing expensive viral load testing, however, there is insufficient data to support the use of CD8 T cell activation measures to detect virological failures under HAART.
But don't be fooled: the virus is under tremendous selective pressure from the immune system and is trying (and largely succeeding) to stay at least a step ahead of neutralizing antibodies and CD8 T cells (and probably other aspects of the immune response).
CD38 expression on CD8 T cells with or without other markers (HLA DR and CD45RA) is not adequate to predict the virological response to antiretroviral therapy (ART) in Ugandans: XVI International AIDS Conference Toronto (Abstr.
ICL patients are a heterogeneous group that may display concurrent CD8 T cell, B cell, or natural killer (NK) T cell lymphocytopenia, and whose clinical manifestations range from asymptomatic to life-threatening infections, including opportunistic pathogens, such as Cryptococcus and non-tuberculous Mycobacteria, with a significant incidence of de novo malignancies and autoimmune phenomena (e.
the vast majority of the HAART treated patients never develop effective HIV specific CD4 and CD8 T cell responses, despite an optimal control of HIV replication and the recovery of a nearly normal CD4 T cell count.
11) Also, broad CD8 T cell responses to multiple HIV antigens were seen in a majority of patients.
One study revealed mostly similar distributions of CD4 and CD8 T cell subsets in LTNPs and patients in the early phase of infection (Clin Diagn Lab Immunol, 5:5, p.
This new study follows positive results from a recently completed study conducted by NIH in collaboration with Kaleidos Pharma demonstrating that TGF alpha increased both CD4 and CD8 T cell counts in SIV-infected monkeys.
Researchers in France compared CD8 T cell responses from 24 patients with documented PHI to CD8 responses from 30 asymptomatic HIV-infected patients who were antiretroviral treatment naive (Abstract 573).
The study focused on a particular type of 'killer' white blood cell, called CD8 T cells, which are critical tumour-fighting cells.
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8 T cells," Journal of Clinical Investigation, 2017; DOI: 10.
In turn, people with fewer CD8 T cells became more seriously ill.