In resource-limited settings this could provide a means of limiting cost by reducing expensive viral load testing, however, there is insufficient data to support the use of
CD8 T cell activation measures to detect virological failures under HAART.
But don't be fooled: the virus is under tremendous selective pressure from the immune system and is trying (and largely succeeding) to stay at least a step ahead of neutralizing antibodies and
CD8 T cells (and probably other aspects of the immune response).
CD38 expression on
CD8 T cells with or without other markers (HLA DR and CD45RA) is not adequate to predict the virological response to antiretroviral therapy (ART) in Ugandans: XVI International AIDS Conference Toronto (Abstr.
ICL patients are a heterogeneous group that may display concurrent
CD8 T cell, B cell, or natural killer (NK) T cell lymphocytopenia, and whose clinical manifestations range from asymptomatic to life-threatening infections, including opportunistic pathogens, such as Cryptococcus and non-tuberculous Mycobacteria, with a significant incidence of de novo malignancies and autoimmune phenomena (e.
the vast majority of the HAART treated patients never develop effective HIV specific CD4 and
CD8 T cell responses, despite an optimal control of HIV replication and the recovery of a nearly normal CD4 T cell count.
11) Also, broad
CD8 T cell responses to multiple HIV antigens were seen in a majority of patients.
One study revealed mostly similar distributions of CD4 and
CD8 T cell subsets in LTNPs and patients in the early phase of infection (Clin Diagn Lab Immunol, 5:5, p.
This new study follows positive results from a recently completed study conducted by NIH in collaboration with Kaleidos Pharma demonstrating that TGF alpha increased both CD4 and
CD8 T cell counts in SIV-infected monkeys.
Researchers in France compared
CD8 T cell responses from 24 patients with documented PHI to CD8 responses from 30 asymptomatic HIV-infected patients who were antiretroviral treatment naive (Abstract 573).
The study focused on a particular type of 'killer' white blood cell, called
CD8 T cells, which are critical tumour-fighting cells.
PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor
CD8 T cells," Journal of Clinical Investigation, 2017; DOI: 10.
In turn, people with fewer
CD8 T cells became more seriously ill.
