IL-17-producing CD8+ T lymphocytes
from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines.
All AIDS patients were found to have highly inverted ratio of CD4+ to CD8+ T lymphocytes
indicating marked immunosuppression.
Burgisser P et al Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment.
Effects of primary HIV-1 infection on subsets of CD4+ and CD8+ T lymphocytes.
Association of depression, CD8+ T lymphocytes
, and natural killer cell activity: Implications for morbidity and mortality in human immunodeficiency virus disease.
Tinhofer I, Marschitz I, Kos M, et al: Differential sensitivity of CD4+ and CD8+ T lymphocytes
to the killing efficacy of Fas (Apo-l/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia Blood 1998; 91:4273-4281
The standard method currently used to count CD4+ and CD8+ T cells in peripheral blood requires an automated hematology analyzer for the determination of the total number of leukocytes and the percentage of lymphocytes (differential blood count) and a flow cytometer to assess the percentage of CD4+ or CD8+ T lymphocytes (5,6).
Earlier, we developed a Capcellia CD4/CD8 immunoenzymatic assay to determine CD4 and CD8 concentrations and the corresponding numbers of CD4+ or CD8+ T lymphocytes in peripheral blood mononuclear cells separated from blood by centrifugation on a Ficoll gradient (10,11).
In adoptive immunotherapy, CD8+ T lymphocytes
targeted to a specific disease (targeted CTLs) are isolated from the patient, expanded to billions of cells ex vivo, and re-administered to the patient.
In a paper (CD4+ T Cells Are Required for Secondary Expansion and Memory in CD8+ T Lymphocytes
, Nature, February 2003) published today in the scientific journal Nature, Stephen P.
in a South African study of vertically infected children, showed that absolute CD38 on CD8+ T lymphocytes
was a predictor of mortality at 1 year, independent of CD4 percentage and viral load .
Tetramer-Based Quantification of Cytomegalovirus (CMV)-Specific CD8+ T Lymphocytes
in T-Cell Depleted Stem Cell Grafts and After Transplantation May Identify Patients At Risk for Progressive CMV Infection.