CD8


Also found in: Dictionary, Thesaurus, Acronyms, Wikipedia.

CD8

a type I transmembrane protein found on suppressor (cytotoxic) T cells, some natural killer cells, and most thymocytes that is involved in T-cell antigen recognition; expressed in some T-cell lymphomas and large granular lymphocyte leukemias.
Farlex Partner Medical Dictionary © Farlex 2012

CD8

(sē′dē-āt′)
n.
A glycoprotein on the surface of killer cells that enhances binding with MHC molecules.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

CD8

T8 antigen A disulfide-linked heterodimeric protein, for which each monomer is 32–34 kD; CD8 is a marker for T cells with suppressor and cytotoxic activity; it is a co-receptor with class I MHC antigens on antigen-presenting cells, and is physically associated with a p56 tyrosine kinase, which phosphorylates adjacent proteins; NK cells may weakly express CD8. See Cytotoxic T cells.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Now the researchers have found that their vaccination strategy marshals a platoon of immune cells, called innate lymphoid cells (ILC1) and monocytes, in the genital tissues to work together and release chemicals (chemokines) to send out a call to the CD8 T-cells generated by the vaccine to troop into the genital tissue.
Kim et al., "Pan-cancer immunogenomic perspective on the tumor microenvironment based on PD-L1 and CD8 T-cell infiltration," Clinical Cancer Research, vol.
To study the mechanism for enhancing the generation of antigen-specific CTLs by UVADEX treatment, we assume that DNA or RNA/ psoralen complexes by UVADEX treatment may mimic CpG DNA structure to activate Toll-like receptors on CD8 T cells.
C, CD8 highlighting the neoplastic cells (original magnifications X20 [A] and X400 [B]; original magnification X200 [C]).
Herzenberg, "Altered representation of naive and memory CD8 T cell subsets in HIV-infected children," The Journal of Clinical Investigation, vol.
The analysis of basic T lymphocyte markers, CD4 and CD8, was shown to be useful in the prognosis for survival in lung cancer after surgery [12, 14, 21-23].
Each cultured PB and SF sample was aliquoted and stained in three different tubes (100 [micro]L/tube) following an intracytoplasmatic permeabilization and staining protocol in order to analyze the intracellular expression of IL-17 within the CD8 T-cell subset.
Phenotype of lymphoid-resident [CD8.sup.+] cDC, CD8 cDC, pDC, nonlymphoid tissue-resident [CDllb.sup.+], [CD103.sup.+], [CD103.sup.+] [CD11b.sup.+] DCs, and Langerhans cells.
The resulting binding, which then triggers the body's defensive activities, is stronger than the sum of the individual binding that would result from the T cell receptor and CD8 co-receptor operating independently.
There is evidence of CD8 T cell, B cell, natural killer (NK) cell, dendritic cell (DC) and macrophage phenotypic activation.