CD8


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CD8

a type I transmembrane protein found on suppressor (cytotoxic) T cells, some natural killer cells, and most thymocytes that is involved in T-cell antigen recognition; expressed in some T-cell lymphomas and large granular lymphocyte leukemias.

CD8

(sē′dē-āt′)
n.
A glycoprotein on the surface of killer cells that enhances binding with MHC molecules.

CD8

T8 antigen A disulfide-linked heterodimeric protein, for which each monomer is 32–34 kD; CD8 is a marker for T cells with suppressor and cytotoxic activity; it is a co-receptor with class I MHC antigens on antigen-presenting cells, and is physically associated with a p56 tyrosine kinase, which phosphorylates adjacent proteins; NK cells may weakly express CD8. See Cytotoxic T cells.
References in periodicals archive ?
Now the researchers have found that their vaccination strategy marshals a platoon of immune cells, called innate lymphoid cells (ILC1) and monocytes, in the genital tissues to work together and release chemicals (chemokines) to send out a call to the CD8 T-cells generated by the vaccine to troop into the genital tissue.
Kim et al., "Pan-cancer immunogenomic perspective on the tumor microenvironment based on PD-L1 and CD8 T-cell infiltration," Clinical Cancer Research, vol.
To study the mechanism for enhancing the generation of antigen-specific CTLs by UVADEX treatment, we assume that DNA or RNA/ psoralen complexes by UVADEX treatment may mimic CpG DNA structure to activate Toll-like receptors on CD8 T cells.
C, CD8 highlighting the neoplastic cells (original magnifications X20 [A] and X400 [B]; original magnification X200 [C]).
Herzenberg, "Altered representation of naive and memory CD8 T cell subsets in HIV-infected children," The Journal of Clinical Investigation, vol.
The analysis of basic T lymphocyte markers, CD4 and CD8, was shown to be useful in the prognosis for survival in lung cancer after surgery [12, 14, 21-23].
Por lo pronto, el hallazgo del mayor numero de linfocitos T CD8 en personas mas resistentes a la influenza, representa la confirmacion del importante papel que juegan estas celulas en los sistemas de defensa del organismo humano, por lo que se podria modificar el enfoque de la busqueda de vacunas antivirales.
Each cultured PB and SF sample was aliquoted and stained in three different tubes (100 [micro]L/tube) following an intracytoplasmatic permeabilization and staining protocol in order to analyze the intracellular expression of IL-17 within the CD8 T-cell subset.
Phenotype of lymphoid-resident [CD8.sup.+] cDC, CD8 cDC, pDC, nonlymphoid tissue-resident [CDllb.sup.+], [CD103.sup.+], [CD103.sup.+] [CD11b.sup.+] DCs, and Langerhans cells.
The resulting binding, which then triggers the body's defensive activities, is stronger than the sum of the individual binding that would result from the T cell receptor and CD8 co-receptor operating independently.
There is evidence of CD8 T cell, B cell, natural killer (NK) cell, dendritic cell (DC) and macrophage phenotypic activation.