CD79a

CD79a

a type I transmembrane protein present on B cells that mediates signal transduction; expressed in mature B-cell neoplasms.
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The monoclonal antibodies (MoAb) used for diagnosis of AL were: for B-lineage: CD19, CD22, CD20, CD10, for T-lineage: CD2, CD3, CD5, CD7, CD4, CD8, for myelo-monocytic lineage: CD13, CD33, CD11c, CD64, CD14, other cells surface markers: CD34, CD117, HLA-DR and intracellular MoAb: CD79a, CD3 and MPO.
Acute myeloid leukemia with t(8;21) often expresses the B-cell markers CD19, CD79a, and PAX5, which is associated with transcriptional upregulation of the PAX5 gene.
These cells expressed CD79a (Figure 1H) and BOB-1 on immunohistochemical staining, but did not express CD20.
The permeabilizing solution containing 15% formaldehyde and 50% diethylene glycol and proprietary permeabilizing agent used for intracellular staining of antigens such as MPO, CD79a, CD3 Cytoplasmic and Tdt.
La expresion positiva de CD79a y MUM1 y negativa de PAX5, CD3 y lisozima concluyeron el diagnostico de linfoma B inmunoblastico.
The large cells with atypical lymphoid characteristics displayed a B-cell phenotype reaction with vimentin, LCA (CD45), CD20 (Figure 1C), and CD79a.
This diagnosis was based on morphology and molecular marker positive for CD20, CD79a, Ki67, Bcl2, and negative or normal patterns for cyclinD1, CD34, CD3, and CD30.
Results of immunohistochemical staining for CD3 and CD79a showed the neoplastic cells were CD3 (Fig 3B) and CD79a-, findings that are consistent with a T-cell lymphoma.
4) and positive Bc-16 as well as positive CD79a and CD10 in cases of Burkitt lymphoma.
All other tested markers (TCA, CD3, CD79a, chromogranin A, synaptophysin, myogenin, desmin, S-100 protein, TdT, LMP1, CD99, TTF-1 and CK-14) were negative, except for a weak expression of neuron-specific enolase (NSE).
To help distinguish seminoma from malignant lymphoma, we added immunostains for CD79a (result: negative) and SALL4 (positive; Figure 4).