Potential first-in-class and best-in-class Antibody Drug Conjugate ('ADC') directed against CD74
, which is highly expressed in many B cell malignancies
According to the results, JUN was in the oncogene family; FOSB, JUN, JUNB, JUND, and KLF were in the transcription factor family; PIM2 and SIK1 were in the protein kinase family; and CXCR4, CD74
, ICAM3, and SDC1 were cell differentiation markers.
is a protein highly expressed in B-cell malignancies such as myeloma and lymphoma.
is the most common fusion partner; however, at least 12 fusion variants have been identified with other partners, including tropomyosin 3 (TPM3), solute carrier family 34 member 2 (SLC34-A2), ezrin (EZR), syndecan 4 (SDC4), leucine rich repeats and immunoglobulin-like domains 3 (LRIG3), KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), golgi-associated PDZ and coiled-coil motif containing (GOPC), and coiled-coil domain containing 6 (CCDC6).
Helicobacter pylori binds to CD74
on gastric epithelial cells and stimulates interleukin-8 production.
Moreover, the levels of protein markers for microglial activation, CD40 and CD74
, were also lower in the presence of rBM-MSC than after LPS stimulation without rBM-MSC, indicating that direct phenotypical activation of microglia was reduced by rBM-MSCs (Supplementary Figure 10).
Different expression and bioinformatic analysis of Microtus fortis in anti-Schistosomiasis Japonica CD74
* ROS1 fusion variants CD74
(C6:R34, C6:R32); SDC4 (S2:R32, S2:R34); SLC34A2 (S13del2046:R32, S13del2046:R34); EZR (E10:R34); TPM3 (T8:R35): Another genetic translocation that results in aberrant receptor tyrosine kinase activity.
The most common ALK fusion variants were EML4-ALKv1 (37.5%), v3 (25%), and v2 (12.5%) whereas the most frequent partners of ROS1 fusions were CD74
) and ezrin (EZR; 24% each).
is a glycoprotein associated with major histocompatibility complex (MHC) class II and functions as an accessory signalling and survival molecule.
pylori colonization, expression of CD74
, and production of proinflammatory mediators in mice [81, 82].