CD74

CD74

a type II transmembrane protein present on B cells, monocytes, dendritic cells, and activated T cells; prevents binding of endogenous peptides; expressed in B-cell chronic lymphocytic leukemia, hairy cell leukemia, and large granular leukocyte lymphomas.
References in periodicals archive ?
Different expression and bioinformatic analysis of Microtus fortis in anti-Schistosomiasis Japonica CD74 gene.
M2 PHARMA-July 18, 2017-Sutro ADC Targets CD74, Eradicates B-Cell Hematologic Malignancy, Prolongs Survival
ROS1 fusion variants CD74 (C6:R34, C6:R32); SDC4 (S2:R32, S2:R34); SLC34A2 (S13del2046:R32, S13del2046:R34); EZR (E10:R34); TPM3 (T8:R35): Another genetic translocation that results in aberrant receptor tyrosine kinase activity.
Develop prioritization within budget in the contract corridors by consulting the CD74, the municipalities of the GCC and the state of Geneva to coordinate actions and to sign the legal documents necessary agreements or other () for carrying out the work on private plots 2.
101) Subsequent FISH and IHC-based screening of primary lung tumors have reported ROS1 rearrangements involving a variety of fusion partners including CD74, SLC34A2, SDC4, EZR, and FIG1 in approximately 1% to 2% of lung ACAs.
Un aumento en los niveles del MIF o de su receptor de superficie celular CD74, se han encontrado en diabeticos que presentan complicaciones microvasculares, como la nefropatia (55, 60), la retinopatia (55, 61, 62) y el sindrome de pie diabetico (63).
Milatuzumab is a new humanized antibody which targets tumors with CD74 antigen, expressed on monocytes, macrophages, and B cells but not on T cells [40].
The allowed claims cover the use of bispecific antibodies targeting CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, of immune cells and CD20 to form a vaccine complex.
University of British Columbia researchers' discovery of the role played by the molecule CD74 could help immunologists investigate treatments that offer better immune responses against cancers, viruses and bacteria, and lead to more efficient vaccines.
For the assessment of monocyte antigen-presenting capacity, we analyzed 2 genes associated with major histocompatibility complex class II (MHCII), HLA-DRA (major histocompatibility complex, class II, DR alpha) and CD74 (CD74 molecule, major histocompatibility complex, class II invariant chain).
Because MIF exerts function through binding to its receptor molecule CD74 and then evokes the following intracellular signals, such as the rapid and transient activation of ERK pathway via CD74-dependent JAB1/CSN5 and Src kinase activity (18,25-27), and the interaction between MIF and CD74 is accompanied with CD44 as a component of the MIF-CD74 receptor complex (28).