CD72 is an inhibitory receptor that regulates the development of lupus-like disease
CD72 is a 45-kDa type II membrane protein mostly expressed in B cells.
There are polymorphisms in both human and mouse CD72.
All these data indicated that CD72 inhibits development of lupus, and that [CD72.
Transcription analysis of 44 CD genes was also carried out, indicating 24 CD genes (CD3E, CD244, CD69, CD247, CD40L, CD38, CD5L, CD44, CD5, CD83, CD163L1, CD36, CD14, CD28, CD200R1A, CD40, CD59, CD200, CD4, CD2, CD72
, CD180, CD79B, and CD93) to be markedly increased by 2.
Alteraciones moleculares han sido tambien observadas en diversos contextos autoinmunes, que incluyen defectos de la senalizacion (70) y apoptosis anormal de linfocitos autorreactivos, (71) o distorsiones en la maquinaria de transduccion estimulada por el CD19 y CD21, o inhibida por el CD22, CD72
Human Lupus Mouse Model NZM Expresses an Allele with Truncation at the Cytoplasmic Domain of CD72.
CD72 is a type II membrane protein expressed in many cell types except T cells and plasma cells.
Analysis of CD72 Expression in Human Tumor Tissues.
Additionally, although CD72, which is an inhibitory receptor for B cell antigen receptor signaling pathways, was not detected as a susceptibility gene by GWASs, it showed significant association with susceptibility to systemic lupus erythematosus in a Japanese study, and it had a 13 bp variable number tandem repeat (VNTR) in the 8th intron.
2012) Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.
Blaupunkt Seattle CD72
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