The expression of CD72 (a regulatory molecule) on B cells is critical in the process of regulating/suppressing B-cell over-activity.
A regulatory role for CD72 expression on B cells in systemic lupus erythematosus.
Sema4D acts as a ligand for receptor plexins (B1, B2, and C1) and CD72 and has been reported to be involved in platelet and neutrophil activation, angiogenesis, and cancer metastasis [10, 46].
Kikutani, "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses," International Immunology, vol.
Some genes involved in B cell activity (CD83 molecule, CD72
molecule, Fc receptor-like 2, FCRL2, and SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1)) are modulated in patients' samples, indicating a concomitant activation of this lymphocyte cell subset in BD.
is an inhibitory receptor that regulates the development of lupus-like disease
(57) Hairy cell leukemia is positive for all common B-cell antigens (CD19, CD20, CD79a, FMC-7, and PAX5), with characteristic expression of annexin A1 (Figure 7, A), CD11c, CD25, CD103, CD123, DBA-44 (CD72
) (Figure 7, B), the Hector Battifora mesothelial epitope-1 (HBME-1), pERK, Tbet, and TRAP58-61 but is typically negative for CD5 and CD10, although 10% to 20% of HCLs are positive for CD10.
Transcription analysis of 44 CD genes was also carried out, indicating 24 CD genes (CD3E, CD244, CD69, CD247, CD40L, CD38, CD5L, CD44, CD5, CD83, CD163L1, CD36, CD14, CD28, CD200R1A, CD40, CD59, CD200, CD4, CD2, CD72
, CD180, CD79B, and CD93) to be markedly increased by 2.1- to 8.4-fold, and 4 CD genes (CD163, CD8A, CD34, and CD7) to be significantly decreased by 2.1- to 8.2-fold in chicken line 6.3 with p < 0.01 and fold [greater than or equal to] 2.
Alteraciones moleculares han sido tambien observadas en diversos contextos autoinmunes, que incluyen defectos de la senalizacion (70) y apoptosis anormal de linfocitos autorreactivos, (71) o distorsiones en la maquinaria de transduccion estimulada por el CD19 y CD21, o inhibida por el CD22, CD72
Human Lupus Mouse Model NZM Expresses an Allele with Truncation at the Cytoplasmic Domain of CD72
. Sarah Odenbach, Cindy Altes, Masashi Ogata, Sheila Stankevitz, Samantha Miller, Yawei Sun, and Bing Yang, Saginaw Valley State University, Biology Department, 7400 Bay Road, University Center, MI 48710
Additionally, although CD72
, which is an inhibitory receptor for B cell antigen receptor signaling pathways, was not detected as a susceptibility gene by GWASs, it showed significant association with susceptibility to systemic lupus erythematosus in a Japanese study, and it had a 13 bp variable number tandem repeat (VNTR) in the 8th intron.
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