The FC studies we conducted showed that CD38, CD71
, and CD30 were positive in 100% of PELs.
United States-based CytomX Therapeutics has advanced CX-2029, a probody drug conjugate aimed at CD71
, which is highly attractive for delivery of cytotoxic payloads to cancer cells, it was reported on Friday.
CytomX Therapeutics teamed up with AbbVie to co-develop and commercialize Probody Drug Conjugates against CD71
, which is highly expressed in a number of solid and hematologic cancers and has molecular properties for efficient delivery of cytotoxic payloads to tumor cells.
Furthermore, upregulated expression of CD71
is considered as a marker of poor prognosis in breast cancer patients .
is highly expressed in a number of solid and hematologic cancers and has attractive molecular properties for efficient delivery of cytotoxic payloads to tumor cells.
BMSCs express a number of nonspecific markers as CD105 (SH2), CD73 (SH3/4), CD44, CD90 (Thy-1), CD71
, and Stro-1, as well as the adhesion molecules CD106 and CD166, intercellular adhesion molecule1, and CD29 .
In the case presented, the myeloblasts were positive for CD34 (Image 3B), megakaryocytes were identified by factor VIII related antigen and CD71
highlighted erythroid precursors (not shown).
The analysis (fluorescence-activated cell sorting, FACS) was performed using CD29, CD34, CD71
, and CD90 as primary fluorescent antibodies and using IgG-FITC and IgG-PE as secondary antibodies.
These still-developing cells, which have a protein on their surface called CD71
, also show up in abundance in the umbilical cord blood of human babies, the team showed.
9 In most cases the blasts are positive for CD34, CD56, CD117, CD13, CD33, CD7, CD4 (dim), CD4, CD42, TPO-R, CD36, CD61 and CD71
Mesenquimales (estromales): CD29, CD44, CD71
, CD90 y CD106
For immunophenotyping, cord blood samples were labelled with CD45, CD34, HLA-DR, CD38, CD71
, CD90, and CD135 after blood count.