CD69

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CD69

a type II transmembrane protein present on platelets, CD4-positive or CD8-positive thymocytes, activated lymphocytes, and activated T or natural killer cells that functions as a signal transducer, enhancing cell activation and/or platelet aggregation.

CD69

A gene on chromosome 12p13 that encodes a member of the calcium-dependent lectin superfamily of type-II transmembrane receptors, the expression of which is induced by T-cell activation. CD69 is involved in lymphocyte proliferation and acts as a signal-transmitting receptor in lymphocytes, natural killer (NK) cells and platelets.
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The expression of CD69 molecule is not restricted to activated lymphocytes, as activated neutrophils and eosinophils can also express CD69.
There are, however, few studies in the literature that assess the function of the CD69 molecule expressed on T lymphocytes in individuals infected with S.
We also evaluated T cell- and NK cell-related genes, including CD3D [CD3d molecule, delta (CD3-TCR complex)], CD69 (CD69 molecule), PRF1 [perforin 1 (pore forming protein)], GNLY (granulysin), CCR3 [chemokine (C-C motif) receptor 3], KLRK1 (killer cell lectin-like receptor subfamily K, member 1), IDO1 (indoleamine 2,3-dioxygenase 1), and KLRD1 (CD94) (killer cell lectin-like receptor subfamily D, member 1).
CD69 molecule in human neutrophils: its expression and role in signal-transducing mechanisms.
The CD69 molecule, the earliest marker of T cell activation, is a member of the C-type animal lectin superfamily of signal transmitting receptors and has recently been cloned [9, 10].
As shown in the Table, the proliferation through the CD69 molecule in the presence of submitogenic doses of PMA (2ng/ml) was also decreased in the elderly (16914 vs.
We assessed the expression and functionality of the CD69 molecule, the earliest surface antigen appearing after T cell activation [22].
Ouabain, at the concentration of [10.sup.-7] M, promoted an increase on the percentage of [CD69.sup.+] monocytes (Figure 1(a)) and a very small increment on the mean density of CD69 molecules per cell (data not shown).