CD68


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CD68

a type I transmembrane protein present on monocytes, macrophages, osteoclasts, mast cells, cytoplasmic granules, activated platelets, and large lymphocytes; expressed in neuroma Schwann cells, in nerves undergoing wallerian degeneration, in myeloid cell tumors, and in anaplastic lymphomas and epithelial tumors.
Farlex Partner Medical Dictionary © Farlex 2012

CD68

A glycoprotein expressed on monocytes and tissue macrophages.
See: cluster of differentiation
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Immunohistochemically strongly positive for S100 protein and various markers especially CD68 and CD163.2 Painless cervical lymphadenopathy with or without extra nodal manifestations are among the most common clinical presentations.3 About 40% of Rosai-Dorfman disease cases have extranodal involvement with predominant head and neck region.
Therefore, purpose of this prospective study was to examine the expression levels of VEGF and CD68 in the rat dental pulp to elucidate their role on vascular angiogenesis, inflammation and odontoblast differentiation in pulp tissue depending on the possible damage of diabetes.
Primary antibodies were as follows: rabbit polyclonal antibody to CD45 (Abcam, Cambridge, Massachusetts), rabbit monoclonal antibody to hemoglobin [alpha] (Boster, Wuhan, China), mouse monoclonal antibody to CD68 (Abcam), and mouse monoclonal antibody to PM-2K (Abcam).
OGC lacks morphologic atypia and typically stains for histomonocytic markers (CD68).
Subsequently, sections were stained with primary antibodies: mouse anti-human 11-Fibrau (1:100 for 60 min at RT), mouse anti-human CD68 (1:100 for 60 min at RT), mouse antihuman CD163 (1:25 for 60 min at RT), rabbit anti-human alpha smooth muscle actin ([alpha]-SMA) (1:400 overnight at 4[degrees]C), or rabbit anti-human Ki67 (1:100 for 60 min at RT).
Significantly increased histiocytes (Figure 1b, highlighted by CD68 immunohistochemistry stain, brown color, arrows) with hemophagocytosis, macrophages engulfing lymphocytes, and cell debris in the cytoplasm (Figure 1c, Liu stain, arrow) were demonstrated.
The immunocytochemical staining showed positive staining for CD68 (green) and OX42 (red), specific cell-markers for microglia, in the 3rd generation of cultured cells, as shown in Figure 1A (c, d).
Numerous lymphocytes, T cells, (CD3, CD4, CD5, and CD8), B cells (L26 and CD19), monocytes/granulocytes, monocytes/macrophages KP-1 (CD68), neutrophil granulocytes, mature B cells, dendritic follicular cells, and HLA-DR (MHC class II cell surface receptor)-positive cells were also present.
Immunohistochemical staining of histiocytic-appearing cells of the dermal infiltrate revealed CD68 and myeloperoxidase reactivity (Figure 2).
Immunohistochemical analysis showed local pan-cytokeratin (+), vimentin (+), P63 (−), cytokeratin 516 (−), CD34 (+), few scattering in the CD68 (+), Ki-67: 50%, the local smooth muscle actin (+), the local S-100 (+), estrogen receptor (−), progesterone receptor (−), E-cadherin (−), dosmin (−), actin (+), the local CD10 (+), and CD117 (−).{Figure 1}
Immunohistochemical (IHC) stains were positive for CD68, S-100 and negative for CD31, which were consistent with MSP (figures 1D, 2A, and 2B).
To determine the polarization status of general macrophage populations in the tumors and their changes with injection of USPIO, immunofluorescence staining of the tumor cross sections was conducted for pan-macrophage (CD68), inflammatory (M1-like AIF1 (allograft inflammatory factor 1)), and wound-healing surface marker phenotypes (M2-like CD206 (mannose receptor)), besides Prussian blue iron histology as the primary observable (Figures 3(a)-3(e)).