CD66e | definition of CD66e by Medical dictionary
a glycosylphosphatidylinositol-anchored membrane protein present in tissues derived from all three germ layers during embryogenesis and adult colon epithelial cells; facilitates calcium-independent adhesion during embryogenesis; expressed in most colon carcinomas and other carcinomas.
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References in periodicals archive
Carcinoembryonic antigen (CEA, also known as CEA-CAM5 or CD66e
) was discovered in malignant tumors of endodermally derived epithelium of the gastrointestinal tract and pancreas .
CEA, now also designated according to the international CD coding system as CD66e
, was subsequently purified in our laboratories in conjunction with John Krupey and Chaim Banjo, and a virtually complete structural analysis of this glycophosphatidyl inositol-bound cell surface glycocalyceal glycoprotein followed (35).
2B) originated from erythrocytes (positive for glycophorin A; median, 4%; interquartile range, 1%-7%) and to a lesser extent ([less than or equal to] 2%) from T-helper cells (CD4), T-suppressor cells (CD8), monocytes (CD14), B cells (CD20), endothelial cells (CD62e), and granulocytes (CD66e