CD62p

CD62p

a type I transmembrane protein present on activated platelets, endothelial cells, and megakaryocytes that facilitates adhesion of monocytes and neutrophils to activated platelets and to endothelial cells.
References in periodicals archive ?
Whole blood was collected and processed, which included red blood cell lysis and blocking with CD16/32 Fc, and the cells were then stained with GR-1, CD62P, or CD41 (eBioscience).
In addition, pECs express the following adhesion molecules: PECAM-1 (CD31), E-selectin (CD62E), P-selectin (CD62P), and vascular cell adhesion molecule-1 (VCAM-1, CD106) [52, 53].
Moreover, they demonstrated that [epsilon]-PLL did not significantly affect the quality of the PCs except for increased CD62P expression.
Mosbeh, "P-selectin (CD62P) expression in liver tissue of biliary atresia: a new perspective in etiopathogenesis," Journal of Pediatric Gastroenterology and Nutrition, vol.
Activated platelets express the cell adhesion molecule P-Selectin (CD62P) [6] on their external surface, and its detection is routinely used to quantify platelet activation levels via flow cytometry using dye-conjugated anti-P-Selectin antibodies [7].
The mechanisms by which platelets and platelet-derived microparticles modulate monocyte or macrophage activity are not fully understood but seem to depend in part on a direct interaction, possibly mediated by adhesion receptors such as CD62P (P-selectin), and in part on the release of soluble factors from platelets [18-20].
Surface platelet expression of P-selectin (CD62P, PADGEM, Platelet Solutions Ltd.) maybe measured remotely in fixed blood [31] and correlates with other measures of platelet function testing [32].
CD162 is expressed in hematopoietic progenitor cells, lymphocytes, and granulocytes and is the only receptor of CD62P (P-selectin) [41].
Later it became evident that PADGEM, GMP-140, or P-selectin identifies the same cell surface molecule and subsequently obtained a number in the cluster of differentiation nomenclature as CD62P [2].
CD62p, also known as P-selectin or granule membrane protein 140 (GMP 140), is a glycoprotein of 140 kDa present in alpha (a)-granules of resting platelets and is translocated to the plasma membrane after activation.
Spearman's correlation coefficient was used to determine the linear relationship between the studied variables and the surface expression of platelet PAC-1 and CD62p. The statistical software package Stata 11.0 (Stata Corp.
Other mechanisms described in the literature include increased activation of Glycoprotein IIb/IIIa, CD41a, CD42b, CD62P and CD6 (3,2,6) prothrombin fragment F1+ 2, thrombin-antithrombin III complex and fibrinopeptide A.