CD62l


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Related to CD62l: CD69, CD44, CCR7

CD62l

a type I transmembrane protein present on B cells, T cells, neutrophils, thymocytes, monocytes, eosinophils, erythroid and myeloid progenitor cells, and natural killer cells; functions as a peripheral lymph node homing receptor and facilitates binding to endothelium at inflammatory sites; found on many malignant leukocytes.

SELL

A gene on chromosome 1q23-q25 that encodes l-selectin, a cell surface adhesion/homing receptor required for binding and rolling of leukocytes on endothelial cells, facilitating leukocyte migration into secondary lymphoid organs and inflammation sites. 

Molecular pathology
SELL polymorphisms are associated with various diseases, including IgA nephropathy.
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Naive cells of [CD4.sup.+] and [CD8.sup.+] stained with CD62L were in greater amount than those stained with CCR7.
The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes.
For example, monocyte expression of CD1 lb, CD54, and CD62L was higher in subjects with asthma than in healthy subjects.
Consistent with literature [24] and our previous results, TGF[beta] induced a regulatory phenotype, indicated by de novo FoxP3 expression in the majority of [CD4.sup.+] cells and upregulation of Treg-associated markers CD25, CD62L, and CTLA4 (Figures 2(a)-2(c)).
Cells were then labeled with the following fluorescence-conjugated monoclonal antibodies: anti-Rat CD45 PE, anti-Rat CD8a APC, anti-Rat CD44 PE, and anti-Rat CD62L (eBioscience, San Diego, CA, USA).
Topical application of beryllium to C3H mice generated beryllium-specific sensitization that was documented by peripheral blood and LN beryllium lymphocyte proliferation tests (BeLPT) and by changes in LN T-cell activation markers, increased expression of CD44, and decreased CD62L. In a sensitization-challenge treatment paradigm, epicutaneous beryllium increased murine ear thickness following chemical challenge.
Sequentially, the soluble forms of sL-selectin and CD62L (bound to the membranes of leukocytes), as well as other adhesion molecules, initiate the emigration of leukocytes, by regulating the flux of rolling neutrophils and inflammatory monocytes [8], playing a critical role for the initiation of leukocyte responses [9].
However, mice receiving 4 [micro]g Hg[Cl.sub.2] had increases in activated phenotype (CD[44.sup.hi]) CD[4.sup.+] T cells (p [is less than] 0.005) and an increase in percentage of CD62L [(Mel-14).sup.lo] CD[4.sup.+] T cells, particularly when compared to the 0.04 [micro]g Hg[Cl.sub.2] group (p [is less than] 0.025).
Lymphocytes were then stained with the use of CD127 FITC (clone HL-7R-M21), CD25 PE (clone 2A3), CD4 PerCP (clone SK3), CD3 V450 (clone UCHT1), CD45RA PEcy7 (clone L48), and CD62L Alexa Fluor750 (clone Dreg-56).