Equillium's initial product candidate, itolizumab (EQ001), is a clinical-stage, first-in-class monoclonal antibody that selectively targets the novel immune checkpoint receptor CD6
plays a central role in modulating the activity and trafficking of T cells that drive a number of immuno-inflammatory diseases.
Equillium announced it has initiated the EQUIP Phase 1b clinical trial of its CD6
targeted therapy, itolizumab, in patients with uncontrolled moderate to severe asthma.
The platform is called CD6
and is a rear-wheel-drive architecture with a longitudinal-engine configuration.
HBB variations Count (n=36) n (%) cd6
and other variations Heterozygosity ([[beta].sup.[sigma]] [[beta].sup.a]) 18 (50.0) Homozygosity ([[beta].sup.[sigma]] [[beta].sup.a]) 18 (50.0) -88-C 3 (8.3) -73A> G 2 (5.6) (-74-A) along with (-75 C>A) 7 (19.4) IVS1.108T>C 2 (5.6) IVS1.110G> A 6 (16.7) HBB--Normal [beta]-globin gene Table 3--Normal [beta]-globin gene variations and treatment among patients in the study.
Also, it was reported that in Yorkshire, CD6
molecule gene (M1GA0002671) regulates the cell adhesion molecules expression in the biological pathways including the development of embryonic cells and nerve tissues, and protein kinase, cGMP-dependent, type II (ASGA0089457, ASGA0103374) is involved in the secretion of luteinizing hormone beta poly-peptide and progesterone .
Meta-analysis of genome scans and replication identify CD6
, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
"Ken Cope for CD6
is our kind of constitutional conservative fighter!
Approximations Sub-bands (Hz) Details Sub-bands (Hz) Ca1 0-10240 Cd1 10240-20480 Ca2 0-5120 Cd2 5120-10240 Ca3 0-2560 Cd3 2560-5120 Ca4 0-1280 Cd4 1280-2560 Ca5 0-640 Cd5 640-1280 Ca6 0-320 Cd6
320-640 Ca7 0-160 Cd7 160-320 Ca8 0-80 Cd8 80-160 Ca9 0-40 Cd9 40-80 TABLE IV.
2010 Population by Council Districts CD1 112,446 CD2 123,574 CD3 118,855 CD4 123,163 CD5 106,608 CD6
152,533 CD7 137,533 CD8 159,568 CD9 159,214 CD10 133,045 Mean 132,654 Figure 1.
In particular, three clusters (CL1, CL5, and CL6) showed a statistically significant enrichment in "T cell-related" gene categories and included several genes typically associated with T cell-mediated immune responses such as: CD3E, CD4, CD6
, CD28, CTLA4, and DUSP2.
and SERPINB5) were included in the model from Eipel et al.