CD57


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CD57

a membrane protein present on natural killer cells, some T cells, a few B cells, and monocytes of unknown function; expressed in large granular lymphocyte leukemias.

CD57

A glucuronyltransferase encoded by B3GAT1 on chromosome 11q25 which is involved in the biosynthesis of the L2/HNK-1 carbohydrate epitope on glycoproteins, and which also plays a role in glycosaminoglycan biosynthesis.

Normal expression
NK cells, oligodendrocytes, Schwann cells, gastric chief cells, gut chromaffin cells, pancreatic islets, renal proximal tubules and loop of Henle, prostatic epithelium, adrenal medulla, epithelial cells of outer thymic cortex, and some fetal bronchial cells.

CD57

A cell surface antigen expressed on many natural killer cells.
See: cluster of differentiation
References in periodicals archive ?
Intensive reaction to CD57 is seen in traumatic neuroma, whereas in schwannoma capsular epithelial membrane antigen (EMA) and CD34 stainings are seen.
Key words: neoplasm, nodule, CD57, immunohistochemistry, Piciformes, wildlife, bird, avian, toco toucan, common toucan, Ramphastos toco
Additional alternative tests, such as urine antigen tests and CD57 tests, have also been shown to be inaccurate (36,37).
They also observed that this response is mediated by age, in reporting an increased proportion of NK-cells expressing the terminal differentiation marker CD57 with advancing years.
The decrease in the CD57 lymphocyte subset may be a marker of Lyme disease (15).
The amount of natural killer cells with an outer CD57 marker can decrease with the presence of Lyme disease, but Babesia, when it is killed, can decrease the levels of this type of cancer killer cell even more.
1) The percentage of activated CD8 T cells expressing both human leukocyte antigen (HLA)-DR and CD57 also was increased in alcoholics with self-reported average alcohol consumption of approximately 400 g/day (Cook et al.
Flow cytometry (FCM) showed CD3 [sup]+ , CD8 [sup]+ , CD57 [sup][+ or -] , CD56[sup]− , and restricted expression of T-cell receptor (TCR)-aa3.
Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer.
8) Actualmente se conocen 65 marcadores inmunohistoquimicos de los cuales los mas estudiados son la proteina acida glial fibrilar, vimentina, antigeno epitelial de membrana, S-100, p53, Ki67, eNOS y CD57, todos ellos utilizados como auxiliares para las diversas opciones terapeuticas.
Immunohistochemical analyses were performed on formalin-fixed paraffin-embedded tissue sections using the avidin-biotin-peroxidase method and antibodies to CD3, CD4, CD5, CD8, CD10, CD20, CD43, CD45, CD56, CD57, CD68, and terminal deoxynucleotidyl transferase (TDT).