TILs express a variety of different antigens on their cell membrane including CD3, CD4, CD8, CD16, CD20, CD56 and
CD57, CD68, CD169 and FOXP3, to regulate the immune system and to suppress tumor growth (Table 1).
Immunohistochemical staining were carried out on the cell block and core biopsy sections using antibodies to thyroid transcriptor factor-1 (TTF-1), Napsin-A, Thyroglobulin, CD10, PAX 8, AMACR, CA19-9 and
CD57 (Automated Ventana Bench Mark machine, the EnVisionTm System).
However, expression of many other markers can be found including NSE, SYNP, chromogranin, CD56,
CD57, S-100, and neurofilament protein.
The tumor cells of the polypoid tumors were positive for pancytokeratin, synaptophysin, chromogranin A,
CD57, protein gene protein 9.5 (PGP9.5), and Ki67 (2% of labeled cells) (Figure 3).
Microscopic examination revealed submucosal S100 positive, EMA, CD34, synaptophysin, CD56,
CD57, GFAP, P53 negative spindle or stellate cells observed in a myxoid matrix.
Flow cytometry was performed to measure surface markers of immune activation on CD4+ and CD8+ T lymphocytes, including CD38, HLA-DR, and
CD57. The expression of CD38 and HLA-DR on CD8+ T cells is a summary measure of HIV-associated immune activation [15], and
CD57 expression on CD8+ T cells is a measure of immune senescence in chronic HIV infection which identifies cells on the pathway of apoptosis [18].
Akbarzadeh, "Prognostic implication of
CD57, CD16, and TGF-[beta] expression in oral squamous cell carcinoma," Journal of Oral Pathology & Medicine, vol.
In addition,
CD57, synaptophysin, chromogranin, vimentin, neuron-specific enolase (NSE), and S-100 are often expressed in EPS tumors [2, 4].
Large numbers of CD3-positive small lymphocytes were noted in the background along with
CD57 cells surrounding the tumor cells, which was consistent with the diagnosis of NLPHL.
In addition, the expression of
CD57 is considered a marker of highly differentiated NK cells [60].
Heuts et al., "Expression patterns of NKG2A, KIR, and
CD57 define a process of CD56dim NKcell differentiation uncoupled from NK-cell education," Blood, vol.