CD57


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CD57

a membrane protein present on natural killer cells, some T cells, a few B cells, and monocytes of unknown function; expressed in large granular lymphocyte leukemias.
Farlex Partner Medical Dictionary © Farlex 2012

CD57

A glucuronyltransferase encoded by B3GAT1 on chromosome 11q25 which is involved in the biosynthesis of the L2/HNK-1 carbohydrate epitope on glycoproteins, and which also plays a role in glycosaminoglycan biosynthesis.

Normal expression
NK cells, oligodendrocytes, Schwann cells, gastric chief cells, gut chromaffin cells, pancreatic islets, renal proximal tubules and loop of Henle, prostatic epithelium, adrenal medulla, epithelial cells of outer thymic cortex, and some fetal bronchial cells.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

CD57

A cell surface antigen expressed on many natural killer cells.
See: cluster of differentiation
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
TILs express a variety of different antigens on their cell membrane including CD3, CD4, CD8, CD16, CD20, CD56 and CD57, CD68, CD169 and FOXP3, to regulate the immune system and to suppress tumor growth (Table 1).
Immunohistochemical staining were carried out on the cell block and core biopsy sections using antibodies to thyroid transcriptor factor-1 (TTF-1), Napsin-A, Thyroglobulin, CD10, PAX 8, AMACR, CA19-9 and CD57 (Automated Ventana Bench Mark machine, the EnVisionTm System).
However, expression of many other markers can be found including NSE, SYNP, chromogranin, CD56, CD57, S-100, and neurofilament protein.
The tumor cells of the polypoid tumors were positive for pancytokeratin, synaptophysin, chromogranin A, CD57, protein gene protein 9.5 (PGP9.5), and Ki67 (2% of labeled cells) (Figure 3).
Microscopic examination revealed submucosal S100 positive, EMA, CD34, synaptophysin, CD56, CD57, GFAP, P53 negative spindle or stellate cells observed in a myxoid matrix.
Flow cytometry was performed to measure surface markers of immune activation on CD4+ and CD8+ T lymphocytes, including CD38, HLA-DR, and CD57. The expression of CD38 and HLA-DR on CD8+ T cells is a summary measure of HIV-associated immune activation [15], and CD57 expression on CD8+ T cells is a measure of immune senescence in chronic HIV infection which identifies cells on the pathway of apoptosis [18].
Akbarzadeh, "Prognostic implication of CD57, CD16, and TGF-[beta] expression in oral squamous cell carcinoma," Journal of Oral Pathology & Medicine, vol.
In addition, CD57, synaptophysin, chromogranin, vimentin, neuron-specific enolase (NSE), and S-100 are often expressed in EPS tumors [2, 4].
Large numbers of CD3-positive small lymphocytes were noted in the background along with CD57 cells surrounding the tumor cells, which was consistent with the diagnosis of NLPHL.
In addition, the expression of CD57 is considered a marker of highly differentiated NK cells [60].
Heuts et al., "Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NKcell differentiation uncoupled from NK-cell education," Blood, vol.