CD53

CD53

a type III transmembrane protein present on leukocytes, platelets, osteoblasts, and osteoclasts; contributes to the transduction of CD2-generated signals in T cells and natural killer cells; facilitates cytoplasmic calcium flux in B cells, monocytes, and granulocytes; and plays a role in activation of the monocyte oxidative burst; expressed in hemopoietic neoplasms and myelomas.
References in periodicals archive ?
The Effect of intensive moderate and downhill running on human blood lymphocytes expressing the adhesion activation molecules CD54 (Icam -1), CD18, and CD53.
However effects on expression of 5 other genes, CDKN2C, FHL1, HGF, IL1RL1, CD53, are associated with tumor growth and carcinogenesis.
To detect the leukocyte plot, a dual-parameter analysis (CD53 fluorescence vs forward-angle light scatter and forward- vs large-angle light scatter) was performed on isolated leukocyte samples by using monoclonal mouse anti-human panleukocyte antigen CD53 (Bio-Rad, Segrate, Italy).
The pellet was resuspended in 100 [micro] L of PBS, and 10 [micro] L of CD53, previously diluted fivefold with PBS, were added.
Indirect immunofluorescence assay for panleukocyte antigen was performed on semen samples by using monoclonal mouse anti-human CD53 (Bio-Rad).
CD53 expression was considered positive only when 20% of the cell population showed a fluorescence signal, because of the high fluorescence background of the sperm.