CD52


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CD52

a glycosylphosphatidylinositol-anchored membrane protein present on thymocytes, T cells, B cells, some granulocytes, seminal vesicles, epididymis, and spermatozoa; plays a role in signal transduction.
References in periodicals archive ?
Therapy of steroid-refractory acute GVHD with CD52 antibody alemtuzumab is effective.
CD52 specific antibody CAMPATH could be used as a safety-switch to rapidly terminate cCAR therapy in mouse models.
Alemtuzumab, a monoclonal antibody directed at CD52. The drug was withdrawn for CLL indication by the producer because of commercial reasons.
Alemtuzumab is a humanized monoclonal IgG1 antibody directed against CD52, a glycoprotein expressed on mononuclear cells, including T- and Blymphocytes, monocytes, and natural killer cells [136, 137].
Alemtuzumab is a humanised monoclonal antibody targeting the CD52 marker present on B and T lymphocytes, monocytes and macrophages.6 The drug has been employed in the management of numerous diseases that include, inter alia, leukaemia, ocular inflammatory disease and organ transplantation.
Alemtuzumab is a monoclonal antibody that recognizes the antigen CD52, a glycoprotein found in various leukocytes, including lymphocytes, monocytes, macrophages and some dendritic cells.
Treatment options for refractory or recurrent disease include alemtuzumab, a monoclonal antibody to the CD52 protein expressed on the surface of mature T cells and possibly NK cells.
Los anticuerpos monoclonales mas usados son aquellos contra el receptor de IL-2 (basiliximab y daclizumab) y el dirigido contra el antigeno CD52 (alemtuzumab).
[12.] Hale G (2001 ) The CD52 antigen and development of the CAMPATH antibodies.
Jiwon Oh of the division of neurology at the University of Toronto analyzed outcomes of pregnancies among women who had been treated with alemtuzumab (Lemtrada), an antibody that targets CD52.
So Qasim and colleagues used a different pair of TALENs to remove a protein called CD52 from the CAR T cells.