CD49e

CD49e

a type I transmembrane protein present on monocytes, neutrophils, leukocytes, fibroblasts, platelets, and myoblasts that helps form a receptor for fibronectin and activates the sodium-hydrogen antiporter; may serve an accessory role to T-cell activation.

ITGA5

A gene on chromosome 12q11-q13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development, differentiation and metastases. Alpha 5 undergoes post-translational cleavage in its extracellular domain, yielding disulfide-linked light and heavy chains that bind to a beta-1 chain, forming a fibronectin and fibrinogen receptor, which also participates in adhesion and cell surface-mediated signalling.

Molecular pathology
The alpha-5 beta-1 heterodimer interacts with extracellular HIV-1 Tat protein, and is thought to enhance angiogenesis in Kaposi's sarcoma.
References in periodicals archive ?
The characterization of IFP-MSCs is based on the presence of cell markers such as CD9, CD10, CD13, CD29, CD44, CD49e, CD59, CD105, CD106, and CD166 [104].
Nine antigens (CD44, CD49e, CD71, CD221, CD227, EGFR, EpCAM, Her2, and Her3) are breast-tumor related and expressed by at least one of the included cell lines (19).
Two outliers were excluded, CD44 and CD49e on HS578T-cells (Fig.
Moreover, P-selectin, CD49d, CD49e, CD49f, and CCR7 all have been identified on the basophil surface and are involved in the IL-3-mediated rolling and adhesion of basophils to endothelial cells [129].
FITC-conjugated mouse anti-human CD49e that reacts with [alpha]5 chain of VLA-5 complex ([alpha]5[beta]1 integrin), FITC-conjugated IgG2 negative control for [alpha]5 subunit from [alpha]5[beta]1 integrin, FITC-conjugated mouse anti-human CD49d that recognizes [alpha]4 subunit of VLA-4 complex ([alpha]4[beta]1 integrin), FITC-conjugated mouse IgG1 negative control for [alpha]4 and [beta]1 subunits, and FITC-conjugated mouse anti-human CD29 antibody that recognizes the [beta]1 subunit of human integrins were purchased from Serotec (UK).
(8,9) Additional positive markers include CD9, CD11c, CD29, CD33, CD43, CD44, CD45, CD49d, CD49e, CD51, CD54, CD71, and the high-affinity immunoglobulin E receptor.
Los antigenos especificos para celulas condrogenicas como CD49c, CD49e, CD49f y CD151 pueden ser evaluados mediante citometria de flujo, segun Grogan et al (21) su expresion indica alta capacidad condrogenica in vitro.
The expression of CD11b was slightly up-regulated, while no significant changes were observed for other adhesion markers(CD11a,CD18,CD29, CD49d, CD49e and CD44; data not shown).
Other surface molecules expressed by both ASCs and BM-MSCs include CD13, CD49e, CD54, CD63, and CD146 [17, 19] (Figure 4).
Flow cytometry analysis demonstrated the dissimilarity between hepatocytes and undifferentiated ADHLSCs as shown by the expression of stromal markers CD90 and CD105, adhesion molecules CD44 and CD49e, immune regulatory molecules CD73 and HO-1, and NK ligands CD112 and CD155.
[34], show that MDS cells are heavily dependent on their "dysplastic niche." MDS-derived MSCs display enhanced supportive capacities for clonal hematopoiesis by decreased expression of cell surface molecules [35], including CD44 and CD49e ([alpha]5-integrin) [36].
In this study, we used flow cytometry to analyse the effects of short-term hypoxic stress on the expression of CD29 (integrin [beta]1), CD44 (HCAM), CD49d (integrin [alpha]4), CD49e (integrin [alpha]5), CD51 (integrin aV), CD61 (integrin [beta]3), and CD184 (CXCR4).