CD49e

CD49e

a type I transmembrane protein present on monocytes, neutrophils, leukocytes, fibroblasts, platelets, and myoblasts that helps form a receptor for fibronectin and activates the sodium-hydrogen antiporter; may serve an accessory role to T-cell activation.

ITGA5

A gene on chromosome 12q11-q13 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development, differentiation and metastases. Alpha 5 undergoes post-translational cleavage in its extracellular domain, yielding disulfide-linked light and heavy chains that bind to a beta-1 chain, forming a fibronectin and fibrinogen receptor, which also participates in adhesion and cell surface-mediated signalling.

Molecular pathology
The alpha-5 beta-1 heterodimer interacts with extracellular HIV-1 Tat protein, and is thought to enhance angiogenesis in Kaposi's sarcoma.
References in periodicals archive ?
8,9) Additional positive markers include CD9, CD11c, CD29, CD33, CD43, CD44, CD45, CD49d, CD49e, CD51, CD54, CD71, and the high-affinity immunoglobulin E receptor.
Los antigenos especificos para celulas condrogenicas como CD49c, CD49e, CD49f y CD151 pueden ser evaluados mediante citometria de flujo, segun Grogan et al (21) su expresion indica alta capacidad condrogenica in vitro.
The expression of CD11b was slightly up-regulated, while no significant changes were observed for other adhesion markers(CD11a,CD18,CD29, CD49d, CD49e and CD44; data not shown).