CD49d


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CD49d

a type I transmembrane protein present on B cells and T cells, natural killer cells, eosinophils, monocytes, erythroblasts, thymocytes, and myoblasts that facilitates cell-cell adhesion and leukocyte migration and aids in lymphocyte activation; expressed in melanomas.

CD49D

This term continues to be used amongst immunologists; the preferred designation in the HUGO database is ITGA4.
References in periodicals archive ?
For the EV Array, the following antibodies were used for capturing: CD11a (HI111) from Ab Biotech (San Diego, CA, USA); Flotillin-1 and TSG101 (5B7) from Abcam (Cambridge, MA, USA); CD3 (HIT3a), CD14 (M5E2), CD16 (3G8), CD28 (L293), CD49d (L25), and CD56 (3G8) from BD Biosciences (Mountain View, CA, USA); CD41 (HIP8), CD63 (MEM-259), HLA-ABC (W6/32), and Alix (3A9) from Biolegend (San Diego, CA, USA); ICAM-1 (R6.
Al estudiar por citometria de flujo, linfocitos B de pacientes con LLC, tambien se han detectado otros marcadores que han sido relacionados con peor pronostico de la enfermedad: ZAP-70, CD38 (28,29) y CD49d (30,31).
CLL cells that migrated out through the vessel walls had signicantly higher levels of several molecules on their surface - the protein CD49d in particular - compared with CLL cells that remained in circulation.
Ademas de los antigenos, para la activacion se usaron los anticuerpos coestimulatorios CD28 (1 [micron]g/ml) y CD49d (1 [micron]g/ml) (Becton Dickinson [R]).
The expression of CD11b was slightly up-regulated, while no significant changes were observed for other adhesion markers(CD11a,CD18,CD29, CD49d, CD49e and CD44; data not shown).
New data on ATL/TV1102, a second generation antisense inhibitor of CD49d, a subunit of VLA-4, for the treatment of RRMS patients, will be presented as well.
8,9) Additional positive markers include CD9, CD11c, CD29, CD33, CD43, CD44, CD45, CD49d, CD49e, CD51, CD54, CD71, and the high-affinity immunoglobulin E receptor.
In healthy subjects, particle exposure with exercise reduced expression of adhesion molecules CD54 and CD18 on monocytes and CD18 and CD49d on granulocytes.
Stimulation was performed with 40 [micro]L/mL (total protein content of approximately 1 [micro]g/mL) of vaccinia viral antigen resuspended according to the manufacturer's instructions (Maine Biotechnology Services, Portland, ME), or 2 [micro]g of CMV antigen (Biowhittaker, Walkersville, MD), always in the presence of co-stimulation with both anti-CD28 and CD49d monoclonal antibodies (1 [micro]g/mL, Becton, Dickinson and Company, Franklin Lakes, N J).
In addition, clinical data will be presented on the investigational compound ATL/ TV-1102, a second generation antisense inhibitor of CD49d, a subunit of VLA-4, for the treatment of RRMS patients.
Alternate theories of the mechanism of sequestration of IVLBCL to the intravascular space include deficient expression of receptors for peanut agglutinin and CD49d, both of which promote homing of tumor cells to endothelial cells via interaction with CD54 and CD106 (CD49d ligand).
FITC PE PE-Cy5 APC 1 [kappa] CD34 CD62L CD38 2 [kappa] CD14 CD44 CD38 3 [kappa] CD126 HLA-DR CD38 4 [kappa] CD117 CD128 CD38 5 [kappa] CD11b CD38 CD3 6 [kappa] CD184 CD38 CD19 7 [kappa] CD45ro CD38 CD10 8 [kappa] CD31 CD38 CD54 9 [kappa] CD50 CD38 CD49d 10 [kappa] CD130 CD38 CD44 11 [kappa] CD56 CD38 CD20 12 [lambda] CD34 CD62L CD38 13 [lambda] CD14 CD44 CD38 14 [lambda] CD126 HLA-DR CD38 15 [lambda] CD117 CD128 CD38 16 [lambda] CD11b CD38 CD3 17 [lambda] CD184 CD38 CD19 18 [lambda] CD45ro CD38 CD10 19 [lambda] CD31 CD38 CD54 20 [lambda] CD50 CD38 CD49d 21 [lambda] CD130 CD38 CD44 22 [lambda] CD56 CD38 CD20 Abbreviations: APC, allophycocyanin; FITC, fluorescein isothiocyanate; PE, phycoerythrin; PE-Cy5, phycoerythrin-Cy5.