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a type I transmembrane protein present on B cells, kidney glomerulus, thyroid, and some basement membranes that may play a role in cell-cell adhesion; expressed in most cultured cell lines.
Farlex Partner Medical Dictionary © Farlex 2012
ITGA3A gene on chromosome 17q21.33 that encodes an integrin alpha-chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that bind to beta-1 chain, forming an integrin that interacts with many extracellular-matrix proteins, together serving as a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.