CD49c


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CD49c

a type I transmembrane protein present on B cells, kidney glomerulus, thyroid, and some basement membranes that may play a role in cell-cell adhesion; expressed in most cultured cell lines.

ITGA3

A gene on chromosome 17q21.33 that encodes an integrin alpha-chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. Alpha 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that bind to beta-1 chain, forming an integrin that interacts with many extracellular-matrix proteins, together serving as a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4.
References in periodicals archive ?
Stem cells derived from human ACL tissue have been shown to express the MSC markers CD13, CD29, CD44, CD49c, CD73, CD90, CD97, CD105, CD146, CD166, SSEA-4, STRO-1, and HLA A, B, C, as well as the pluripotency markers Oct4, Nanog, and Sox2, and demonstrate negative expression of CD34 and CD45 [20-22,25].
The cells consistently differentiated into three lineages in culture, were negative for hematopoietic markers (CD34, CD36, CD117, and CD45), and were positive for mesenchymal markers CD29 (95%), CD44 (>93%), CD49c (99%), CD49f (>70%), CD59 (>99%), CD90 (>99%), CD105 (>99%), and CD166 (>99%).
Los antigenos especificos para celulas condrogenicas como CD49c, CD49e, CD49f y CD151 pueden ser evaluados mediante citometria de flujo, segun Grogan et al (21) su expresion indica alta capacidad condrogenica in vitro.