CD49a


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CD49a

a type I transmembrane protein present on activated T cells, B cells, monocytes, neurovascular endothelium, and smooth muscle that forms a receptor for collagen and laminin; expressed on melanomas.
Farlex Partner Medical Dictionary © Farlex 2012

ITGA1

A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. The alpha-1 beta-1 heterodimer forms a cell surface receptor for collagen and laminin, is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
In addition to the whole range of MSC surface markers, including CD73, CD90, and CD105, MenSCs also express some pluripotency markers, such as OCT-4, SSEA-4 [17,21], highly upregulated levels of CD49a [22] but lack of STRO1 expression [23, 24], which further distinguishes them from BMMSCs.
dNK cells are characterized by a [CD56.sup.superbright][CD16.sup.-] phenotype, along with the expression of specific surface markers, such as CD9 (a tetraspanin protein family that plays a role in cell adhesion and cell motility), CD49a (an integrin alpha subunit that binds collagen and laminin), and CD69, an early activation molecule [7, 16, 17].
We investigated the expression of dNK surface marker expression (CD9 and CD49a) on PE-NK cells.
For example, several integrins such as [[alpha].sub.1] integrin (CD49A), [[alpha].sub.2] integrin (CD49B), [[alpha].sub.2b] integrin (CD41), and [[beta].sub.1] integrin (CD29) were upregulated in the liver metastasizing cell line, whereas angiopoetin 1 and MMP10 were upregulated genes of the peritoneal disseminating cell line.
SLL and vascular smooth muscle moderately, and vascular endothelium and especially capillaries strongly expressed CD49a, b, c, f, and CD29 in both the normal and the OA groups (Fig.
Moreover, dNK cells have a high expression of killer cell lectinlike receptor subfamily D (KLRD1) [27], CD9 [28], and CD49a [29] and an increased frequency of expression of CD69 [22].
Three different NK subsets have been characterized on the basis of distinctive surface antigen expression and described as (a) [CD56.sup.dim][CD16.sup.+] that represents the conventional cytotoxic NKs, characterized by the high release of perforin and granzymes; (b) [CD56.sup.bright][CD16.sup.-] that are able to release a large amount of cytokines; (c) [CD56.sup.superbright][CD16.sup.-] that are able to produce proangiogenic factors, including VEGF, IL-8, and SDF-1 and are characterized by the expression of specific surface markers as CD9 and CD49a.
Threecolor staining--fluorescein-isothiocyanate, phycoerythrin, and allophycocyanin-conjugated primary antibodies against ABCG2, CD31, CD34, CD44, CD47, CD49a, CD49d, CD51, CD73, CD90, CD105, and Nestin--were applied for 30 minutes at 4[degrees]C.
Adhesion molecules CD51, CD49a, CD49d, and integrin-related CD47 showed an increased expression, with no significant difference being detected between the conditions.
Numerous putative human MSC surface markers (i.e., CD49a [23], CD73 [1], CD105 [46], CD106 [47], CD271 [22], MSC antigen-1 [48], Stro-1 [49], and stage-specific embryonic antigen-4 [50]) have been identified thus far.
ADSC were positive for CD13, 44, CD49a, CD63, CD73, CD90, CD105, and CD166.
described a perivascular population residing in human fetal and term placenta, which co-expressed MSC/PC markers (Stro-1, 3G5, CD105, CD106, CD146, CD49a, [alpha]-MA) but not hematovascular markers (CD117, CD34, vWF) and were competent for trilineage mesenchymal differentiation [79].