CD49a | definition of CD49a by Medical dictionary
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a type I transmembrane protein present on activated T cells, B cells, monocytes, neurovascular endothelium, and smooth muscle that forms a receptor for collagen and laminin; expressed on melanomas.
ITGA1 A gene on chromosome 5q11.2 that encodes an integrin alpha chain protein which, like all integrins, forms a heterodimer with a beta chain, thereby participating in an array of cell-cell and cell-matrix interactions, playing a major role in cell migration, organ and tissue development and differentiation. The alpha-1 beta-1 heterodimer forms a cell surface receptor for collagen and laminin, is involved in cell-cell adhesion and may play a role in inflammation and fibrosis.
References in periodicals archive
SLL and vascular smooth muscle moderately, and vascular endothelium and especially capillaries strongly expressed CD49a
, b, c, f, and CD29 in both the normal and the OA groups (Fig.