SGN-CD48A is an investigational ADC targeted to the protein CD48
, which is highly expressed on MM cells.
For gene expression in LTHSCs as well as in MPPs using the Slam marker staining (including CD150 and CD48
), the CelluLyser[TM] protocol (TaTaa, Gothenburg, Sweden) was used according to the manufacturer's protocol.
Members of tetraspanins, CD82 and CD63, members of integrin's family LFA-1, integrin [beta]1, CD11b, and integrin [alpha]v[beta]6, and members of Ig superfamily ICAM-1 and CD48
also show interaction of EBV glycoproteins and CD21 .
Gene expression array analysis revealed that expression of CD48
, a glypiated-linked protein in the signaling lymphocyte activation molecule family, was inversely correlated with Gfi1 expression.
In contrast, 23 CD genes (CD3E, CD69, CD48
, CD274, CD40L, CD59, CD40, CD93, CD247, CD28, CD5L, CD38, CD44, CD200R1A, CD14, CD5, CD83, CD2, CD200, CD4, CD79B, CD72, and CD180) were significantly increased by 2.1- to 8.7-fold while 2 CD genes (CD163 and CD36) were significantly decreased by 5.0- and 6.8-fold in chicken line, 7.2 with p < 0.01 and fold [greater than or equal to] 2 (Supplemtary Table S5.
Keywords: WM-68 cell line; anti CD48
antibody; Hybridoma, 0.5% FBS, serum free.
More recently, a study has shown that the HERV-K18 retrovirus, through its CD48
region, participates in the pathogenesis of T1DM.
In addition, CD48
the proposed ligand for CD2, shows at least 47 different glycan structures (18).
In the comparison of B-CLL and myeloid leukemia, most of the statistically significant probes with higher hybridization signals in B-CLL samples represented B lymphocyte-associated genes, such as BTG1, CD79A, FAIM3, CCR7, CD48
, and HLA-DRA (28).
In the July 6 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, the researchers identify CD48
, which adorns the surface of mast cells, as the protein that performs that binding.