Citation: "Thrombospondin-1 Signaling through CD47
Inhibits Self-renewal by Regulating c-Myc and Other Stem Cell Transcription Factors"; Sukhbir Kaur et al.; Scientific Reports, 2013; 3 DOI: 10.1038/srep01673
According to Isenberg, "These experiments indicate that we can lake a primary human or other mammalian cell, even a mature adult cell, and by targeting CD47
turn on its pluripotent capability.
The latter is an antibody-like Fc fusion protein that targets the CD47
protein with high affinity, facilitating the elimination of cancer cells and cancer stem cells by the patient's own immune system.
TTI-621 is designed to augment the immune system's ability to destroy cancer stem cells by targeting the protein CD47
. TTI621--expected to enter formal clinical studies in the second quarter of this year--is being developed initially as a treatment for acute myeloid leukemia, with potential applications in other hematological and solid tumors.
The expression of CD47
(15) and phosphatidylserine (PS) exposure on the outer membrane were also measured.
La proteina CD47
funciona en los seres humanos como una senal de "no me comas" ante los macrofagos, los fagocitos que se encargan de liberarnos de microbios y celulas inservibles.
But first, free-floating thrombospondin has to bind to CD47
on the blood cell surface.
For pig passage benchmarking, there is CDI's CD47
time based system.
Forty Seven (FTSV) and Ono Pharmaceutical (OPHLY) announced an exclusive license agreement for the development, manufacture and commercialization of 5F9, Forty Seven's monoclonal antibody against CD47
. The agreement includes all therapeutic uses of 5F9 as a monotherapy or combination agent in Japan, South Korea, Taiwan and the ASEAN countries.
ALX148, designed for combination therapy, is a fusion protein comprised of an engineered high affinity CD47
binding domain of SIRP?
IBI188, which is a fully human monoclonal antibody targeting CD47
, can bind to the CD47
antigen on the surface of tumour cells, block the CD47-SIRP?
Burvenich, "Influence of sex steroids on the viability and CD11b, CD18 and CD47
expression of blood neutrophils from dairy cows in the last month of gestation," Veterinary Research, vol.