CD46


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CD46

a type I transmembrane protein present on thymocytes, T cells, B cells, natural killer cells, monocytes, neutrophils, platelets, endothelial cells, epithelial cells, fibroblasts, placenta, and sperm that protects against complement-mediated damage.
References in periodicals archive ?
Association of CD46 IVS1-1724 C>G single nucleotide polymorphism in Iranian women with unexplained recurrent spontaneous abortion (URSA).
Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor.
The protein, known as CD46, is found on the surface of immune cells.
These include mutations in genes coding for Factor H, CD46 (MCP), Factor I, Factor B, and C3.
Membrane cofactor protein (MCP or CD46) mutations: These mutations are the mutations of CD46 which is one of the regulatory proteins of the alternative complement system and also known as MCP.
Functional characterization of two novel non synonymous alterations in CD46 and a Q950H change in factor H found in atypical hemolytic uremic syndrome patients.
Among Morbilliviruses the vaccine strain of measles virus (MV) is also known to be capable of using CD46 along with SLAM receptor (Tatsuo et al.
Las proteinas reguladoras del complemento (CD55, CD46 y CD59) confieren resistencia al dano celular y se encuentra baja expresion en los astrocitos, lo que puede explicar su mayor dano con respecto a otras celulas de la periferia que expresan AQP4 [12]distinct from multiple sclerosis, causing inflammatory lesions in the optic nerves and spinal cord.
Also called membrane cofactor protein (MCP), CD46 is the cofactor for factor I-mediated degradation of C3b and C4b, which prevents the continuous formation of convertases.
Part II discusses pathogens, covering gp41 in HIV defense, LC3 in hepatitis infection, unfolded proteins in immune suppression, mycobacteria, parasitic protists, the CD46 receptor, and Helicobacter pylori.
In addition, simultaneous expression of multi-genes, such as human complement regulatory protein (hDAF, CD46, CD59), is needed to protect from HAR and AHXR.