CD44 molecule | definition of CD44 molecule by Medical dictionary
CD44 (redirected from CD44 molecule)
a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.
CD44 A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive
These cells furthermore showed low expression levels of the stem cell marker CD44 molecule
(Indian blood group; CD44) and high expression levels for Wolf-Hirschhorn syndrome candidate 1 (Whsc1), a gene encoding for histone methyltransferase NSD2 known to play an important role in cancer proliferation, survival, and tumor growth (16).
Earlier investigators postulated a potential role for the CD44 molecule
in tumor metastasis via the homing effects to lymphoid tissues.
The CD44 structure of normal cells is distinct from that of cancer cells because pathological conditions promote alternate splicing and posttranslational modifications to produce diversified CD44 molecules
with increased tumorigenicity [22, 23].
The biological role of the CD44 molecules
is not the same in all tumors.