CD44


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CD44

a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.

CD44

A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive ?
Conclusion: Micro ribonucleic acid 34-a might suppress the progression of neuroblastoma through inhibiting the expression of the potential target gene CD44.
At the completion of the TIFP measurement, tumors were excised, formalin fixed and processed for CD44 expression.
CD44 and its role in inflammation and inflammatory diseases.
Flat intraurothelial neoplasia exhibiting diffuse immunoreactivity for CD44 and cytokeratin 5 (urothelial stem cell/basal cell markers): a variant of intraurothelial neoplasia commonly associated with muscle-invasive urothelial carcinoma [published online ahead of print March 17, 2016].
Previous reports suggested the existence of tumor stem cells that are characterized by upregulation of CD44 and the downregulation of CD24 (34).
CD44 isoform 6 (CD44v6) is a prognostic indicator of the response to neoadjuvant chemotherapy in cervical carcinoma.
While Bassarova et al have suggested that new molecular regulators of cell death (Bax) and cell-cell adhesion (cadherins and CD44 isoforms) might be useful in predicting the aggressiveness of PC, (32) there is still no immunohistochemical or flow cytometric analysis that has been able to definitively differentiate pilomatrixoma from its less common malignant counterpart.
The phenotypes of the bone-marrow MSCs were determined using flow cytometry for the absence of CD34 and the presence of CD44 and CD90.
The receptor CD44 has been functionally associated with the "tumor initiating cell" properties in TNBC.
The OncAlert Oral Cancer Risk Assessment System includes the OncAlert Oral Cancer Rapid point-of-care risk assessment test and the OncAlert Oral Cancer CD44 + Total Protein Lab Test.