CD44


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CD44

a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.

CD44

A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive ?
One of the markers used to define this difficult to eradicate cell population is CD44, which is specifically targeted by Alchemia's HyACT technology.
50) The normal urothelium shows CK20 positivity confined to the umbrella cell layer, CD44 positivity in the basal cell layer, and a weak and patchy p53 nuclear staining.
Welsh and her team plan to examine the independent and interactive effects of vitamin D and other natural products on HA metabolism and CD44 signaling in TNBC models.
Preoperative p53, bcl-2, CD44 and E-cadherin immunohistochemistry as predictors of biochemical relapse after radical prostatectomy.
Preventative strategies might then be developed for people living in high-ozone areas who cany CD44 and I[alpha]I SNPs, or individuals who develop inflammatory lung disease might be studied for targeted therapies.
The test measures soluble CD44 and total protein levels -- specific protein markers known to indicate early stage cancers -- in an oral rinse, to serve as an aid in diagnosis of oral cancer, along with other clinical factors.
11) Markers include non-organic compounds; proteins including CD44, IL-8, cyclin D, and many others; DNAs including p53; mRNA including 11-8, OAZ1, and SAT, among others; microRNAs; oxidative stress-related molecules including peroxidase and superoxide dismutase; metabolomics; glycosylation-related molecules; and enzymes such as telemorase.
CD44 controls cell-cell interactions and is related to cross-talk between cancer stem-like cells and their microenvironment (Al-Hajj et al.
This analysis revealed three top-ranking pathways, which are listed in their respective order: complement and coagulation cascades (14 downregulated genes in the H group), systemic lupus erythematosus (14/16 downregulated genes in the H group) and ECM -receptor interactions (7 downregulated genes, including collagen, type IV, alpha 6 (COL4A6), tenascin C (TNC), secreted phosphoprotein 1 (SPP1), collagen, type I, alpha 2 (COL1A2), COL1A1, CD44 molecule (CD44), and ribosomal protein L26 (RPL26), and 5 upregulated genes, including integrin, beta 6 (ITGB6), syndecan 4 (SDC4), agrin (AGRN), thrombospondin 4 (THBS4), BT.
The hUDSCs were harvested and ThehUDSCs were harvested and labeled with antibodies against CD45, CD34, CD90, CD105, CD133, and CD44.
amcure's series of development candidates specifically binds to a special isoform of the surface molecule CD44, thus interfering with central signalling pathways in tumour growth.
However, HER2-positive cancers usually grow faster than HER2-negative cancers (25) and are associated with high serum CD44 values, which affect overall survival (26).