CD44


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CD44

a type I transmembrane protein present on T cells, pre-B cells, monocytes, neutrophils, CNS white matter, fibroblasts, skeletal muscle, and medullary thymocytes; facilitates lymphocyte binding to endothelial venules and assists in adhesion.

CD44

A gene on chromosome 11q13 that encodes a cell surface glycoprotein involved in cell–cell interactions, cell adhesion and cell migration, and which is a receptor for hyaluronic acid. CD44 also interacts with other ligands—e.g., osteopontin, collagens and matrix metalloproteinases—and participates in a range of cellular functions including lymphocyte activation, recirculation and homing, haematopoiesis and tumour metastasis.
References in periodicals archive ?
The samples were blocked by 10% (v/v) goat serum for 30 min, then incubated in 1% BSA containing the following polyclonal antibodies: (1) rabbit anti-sheep Oct-4 (1:100); (2) rabbit anti-sheep CD29 (1:100); (3) rabbit anti-sheep CD44 (1:100); (4) rabbit anti-sheep CD71 (1:100); (5) rabbit anti-sheep CD73 (1:100) and (6) rabbit anti-sheep CD90 (1:100) for 1h at room temperature.
The samples were analyzed by immunohistochemistry of CD29, CD44, CD90, and CD45 and observed by light microscopy.[14] Fibroblasts were also cultured on glass coverslips in six-well plates for 7 days and then analyzed by immunohistochemistry of fibroblast-specific protein-1 (FSP-1).
Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.
Flat intraurothelial neoplasia exhibiting diffuse immunoreactivity for CD44 and cytokeratin 5 (urothelial stem cell/basal cell markers): a variant of intraurothelial neoplasia commonly associated with muscle-invasive urothelial carcinoma [published online ahead of print March 17, 2017].
Flow cytometry was performed using markers of mouse MSCs (CD44, CD90.2), hematopoietic stem cells (CD34), and leukocytes (CD45).
Consistent with CD13 expression, the combination of IL-1[beta] + TNF-[alpha] (p [less than or equal to] 0.01) and IL-6 + IL-1[beta] + TNF-[alpha] (p [less than or equal to] 0.05) [+ or -] TIMP-1 (p [less than or equal to] 0.01) induced a significantly higher CD44 expression in CB-derived [CD34.sup.+] cells (>2-fold increase, respectively; Figure 1(d)).
Yeh et al., "Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells," Onco-target, vol.
Hyaluronic acid (HA) binds to its receptor (CD44) to participate in the regulation of tumor growth and metastasis.
Additionally, fluorescent reporter assay was used to clear the targeting site of micro ribonucleic acid 34-a and CD44. Furthermore, protein levels of CD44, the putative target gene of micro ribonucleic acid 34-a, was assessed after transfection by Western blot.
One accepted marker of cancer stem cells is CD44, the receptor for hyaluronic acid (HA).
SNP correlated with TNF) [21-23] and presence of H blood group antigens on CD44 adhesion molecule.