GP5

(redirected from CD42d)

GP5

A gene on chromosome 3q29 that encodes a protein which is part of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis.

References in periodicals archive ?

There is absence of aggregation response with ristocetin on platelet aggregation studies with normal aggregation with other aggregating agents.8 BSS diagnosis is confirmed by Flow cytometric analysis of platelets showing defective binding with CD42a (GPIX), CD42b (GP Ib[alpha]), CD42c (GP Ib[beta]), and CD42d (GPV) antibodies.9 The defective fragments of GP Ib-IX-V complex after separating with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) may be identified by immunobloating.10

Bernard Soulier Syndrome: 10 years' experience at a tertiary care hospital

561911) or FITC-conjugated CD42d (Emfret Analytics, Cat.

The advanced maturation state of megakaryocytes from stressed mice suggested by morphological examination was sustained by the enhanced expression of lineage differentiation marker CD42d (Figure 6(f), p <0.01).

Apocynin Prevents Abnormal Megakaryopoiesis and Platelet Activation Induced by Chronic Stress

This disease is caused by mutations in one of the three genes coding for the glycoprotein complex (GP)-IX-V 1b (CD42b-CD42a, CD42d), which function as a receptor for vWF, also affecting platelet adhesion and aggregation.

PLATELET DISORDERS: Generation of human experimental models of Bernard-Soulier Syndrome and Glanzmann Disease using cellular reprogramming