GP1BA

(redirected from CD42b antigen)

GP1BA

A gene on chromosome 17pter-p12 that encodes the alpha subunit of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor (vWF) receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis. The alpha subunit provides the vWF binding site.

Molecular pathology
GP1BA polymorphisms and mutations are linked to Bernard-Soulier syndromes and platelet-type von Willebrand disease.
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Platelet activation occurs during cold storage, so residual PLTs in stored blood components may give rise to MPs displaying the CD42b antigen. By itself, fluorescent antibody binding to CD42b cannot distinguish PDMPs from PLTs or other particles to which CD42b might be transferred, but "events" (cells or particles) detected by flow cytometry can be characterized by their fluorescence and lights-cattering properties.