Positive effects of combined antiretroviral therapy on CD4+ T cell
homeostasis and function in advanced HIV disease.
CD127 and CD25 Expression defines CD4+ T cell
subsets that are differentially depleted during HIV infection.
Comparison of capillary based micro-flurometric assay for CD4+ T cell
count estimation with dual platform Flow cytometry.
Regulation of Virus-Specific CD4+ T cell
function by multiple costimulatory receptors during chronic HIV infection.
The CD4+ T cell
count estimation became an important parameter for monitoring immune deficiency after the discovery of the acquired immune deficiency syndrome (AIDS).
Consequently, T cell activation and turnover correlate well with disease progression [11,12] and the rate of CD4+ T cell
In all, these data suggest that the direct consequences of high level virus replication alone cannot account for the progressive CD4+ T cell
depletion leading to AIDS, and that active antiviral cellular immune responses may not always be beneficial.
Vigorous HIV-1-specific CD4+ T cell
responses associated with control of viremia.
Finally, the CD4+ T cell
counts determined by flow cytometry and Capcellia on blood samples from 21 HIV-1-infected patients receiving antiretroviral treatment (zidovudine + didanosine) over an 18-week period were similar.
The repeated treatment cycles of CYT107 in this study mimic the way the product will be used in the clinical setting and should trigger an improved and more prolonged immune reconstitution, a stabilization of patient CD4+ T cell
counts above 500/oL, and a decrease of the markers of activation/inflammation," said Michel Morre, DVM, President and CEO of Cytheris.
The strength of the recommendation to treat asymptomatic patients should be based on the willingness and readiness of the individual to begin therapy; the degree of existing immunodeficiency as determined by the CD4+ T cell
count; the risk of disease progression as determined by the CD4+ T cell
count and level of plasma HIV RNA; the potential benefits and risks of initiating therapy in asymptomatic individuals; and the likelihood, after counseling and education, of adherence to the prescribed treatment regimen.
Sustained CD4+ T cell
response after virologic failure of protease inhibitor-based regimens in patients with human immunodeficiency virus infection.