CD4


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CD4

 
designation for an antigen found on helper T cells; see under antigen.

CD4

a type I transmembrane protein found on helper/inducer T cells, monocytes, macrophages, and dendritic cells that is involved in T-cell recognition of antigens; expressed in mycosis fungoides, Sézary syndrome, and T-cell lymphomas.

CD4

(sē′dē-fôr′)
n.
A glycoprotein predominantly found on the surface of helper T cells. In humans, it is a receptor for HIV, enabling the virus to gain entry into its host.

CD4

A transmembrane glycoprotein present on T helper/inducer cells, which participates in adherence of T cells to target cells, and is involved in thymic maturation and transmission of intracellular signals during T cell activation by the class II MHC; CD4 has inducer or helper activity for T cell, B cell, and macrophage interactions, and evokes T cell proliferation in response to soluble antigens or autologous non-T cells, providing appropriate signals for B cell proliferation and differentiation into Ig-secreting cells; CD4 is also a high-affinity receptor for HIV-1's gp120, binding 42–55 of the NH2 terminal domain amino acids, and has an Ig-like fold similar to the complementarity-determining region of the kappa light chain; CD4 also binds Igs independently of the Fc receptor, and is an accessory to the T-cell receptor

CD4

A type of protein molecule in human blood that is present on the surface of 65% of human T cells. CD4 is a receptor for the HIV virus. When the HIV virus infects cells with CD4 surface proteins, it depletes the number of T cells, B cells, natural killer cells, and monocytes in the patient's blood. Most of the damage to an AIDS patient's immune system is done by the virus' destruction of CD4+ lymphocytes. CD4 is sometimes called the T4 antigen.
Mentioned in: AIDS, AIDS Tests
References in periodicals archive ?
LF-LAM may be used to assist in the diagnosis of active TB in adult inpatients living with HIV, with signs and symptoms of TB (pulmonary and/or extrapulmonary), who have a CD4 count less than or equal to 100 cells/[micro]l, or people living with HIV who are seriously ill, regardless of CD4 cell count or with unknown CD4 cell count.
Among people who reached a CD4 count above 500 cells/[mm.sup.3] for at least 2 years on ART, lung cancer incidence became nearly equivalent in people with and without HIV (SIR 0.9, 95% CI 0.6 to 1.3) but not in people with two other non-AIDS cancers, Hodgkin lymphoma (SIR 9.4, 95% CI 7.9 to 16.8) and liver cancer (SIR 2.4, 95% CI 1.4 to 4.1).
For objective 1, the CD4 cell count value was log transformed due to its skewed distribution, and a linear regression model was built to assess the association between blood pressure (systolic and diastolic) and log CD4 cell count, both as continuous variables.
We expect that the VISITECT CD4 test will make a real difference in HIV treatment and prevention programs that care for many millions of patients worldwide, which is exactly what we set out to achieve.
Correlating CD4 values with TLC, we derive that in our study population 33 patients who had CD4 counts less than 200 had a mean TLC of 1198.
The percentages of patients with CD4 counts in the ranges of <100, 101-200, 201-350, 351-500 and >500 cells/[micro]L in the financial years 2010/11 and 2014/15 are set out in Table 1, according to province.
During our study period, 32% (n = 1,996) of Oregon's HIV-infected population had [greater than or equal to]1 CD4 count <200 cells/[mm.sup.3] and 10.9% (n = 677) had [greater than or equal to]1 CD4 count <50 cells/[mm.sup.3], indicating a relatively small population at theoretic risk for disseminated NTM.
Table 1: Percentages of CD4 and CD8 and absolute CD4 and CD8 counts before and after immunization in the controller and noncontroller groups and total population.
Detection of CD4(+) T-cell antibodies in a patient with idiopathic CD4 T lymphocytopenia and cryptococcal meningitis.
Key Words: Idiopathic CD4 Lymphocytopenia (ICL); Adrenal Histoplasmosis; Histoplasma Infection