It also gained option rights to IPH5201, an antibody targeting CD39
, as well as four preclinical molecules from Innate Pharma's pipeline.
The data highlight the mechanisms of targeting CD73 and CD39
, which are distinct targets in the adenosine axis and focal points of the Surface Oncology pipeline.
Montler et al., "Co-expression of CD39
and CD103 identifies tumor-reactive CD8 T cells in human solid tumors," Nature Communications, vol.
Shi et al., "Expression of CD39
mRNA is altered in the peripheral blood of patients with allergic asthma," Biomedical Reports, vol.
It was confirmed that CD39
was related to the stability and the suppressive function of Treg cells .
The canonical pathway is started by CD39
, an ectonucleoside triphosphate diphosphohydrolase (NTPDase), which converts ATP to ADP.
For Treg identification, 100 [micro]L of marrow blood was incubated with a lyophilised pellet of CD45RA FITC, CD25 PE, CD127 PerCP-Cy 5.5, HLA-DR PE-CY[TM]7, CD39
APC, and CD4 APC-H7 MoAbs (BD Pharmingen).
Other studies have suggested that IL-27 exerts some of its tumor promoting effects through induction of immune regulatory phenotypes, such as increasing the expression of molecules like IL-18BP , PD-L1/2 [23, 24], IDO , CD39
, Tim3 , and IL-10 .
Low-grade hypoxia promotes intestinal barrier function by inducing the expression of genes such as trefoil factor 3, mucin-3, multidrug resistance protein 1, CD39
, CD73, and creatine kinases in IECs [75-78].
The company has built a pipeline of immune checkpoint modulators for targets including PD-1, TIM-3, CD39
, and others.
Adenosine is a highly bioactive molecule, which is stored inside cells as adenosine triphosphate (ATP) and transported to the extracellular space by transporter molecules or catabolized into adenosine extracellularly by ectoenzymes CD39
and CD73 [1, 2].