CD37

CD37

a type III transmembrane protein present on mature B cells, some T cells, and monocytes that may play a role in ion transport; expressed on B-cell lymphomas, B-cell chronic lymphocytic leukemia, and hairy cell leukemia.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
A phase I study of IMGN529, an antibody-drag conjugate (ADC) targeting CD37, in adult patients with relapsed or refractory b-cell nonhodgkin's lymphoma (NHL).
Analysis of preclinical and clinical samples after treatment with a CD37 targeting antibody drug conjugate (AGS67E) support a high level of CD37 expression in NHL.
Cytokines including interferons, lymphokines, interleukins, and chemokines bind to various receptors, for example, IL1 and IL2 receptor types, IFN, CD40, CD37, CD30, CD4, CCR5, and IL1-17R receptor family.
One proposed mechanism for T cell suppression is the extracellular adenosine production by exosomes exposing CD39 and CD37 on their surface [29].
Immunological markers Functional Regulatory Adhesion Lineage-specific and others HLA-DR CTLA-4 CD11a CD3 HLA-ABC PD-L1 ICAM-1 CD4 CD28 CD8 CD80 CD14 CD49d CD16 TLR3 CD19 Fas-L CD37 MIC A/B CD41 TNF RI CD42a TNF RII CD45 CD56 CD83 Vesicle-related markers Functional Tetraspanins Others HLA-DR CD9 TSG101 HLA-ABC CD63 Alix CD28 CD81 Flotillin-1 CD80 CD82 Annexin V CD49d TLR3 Fas-L MIC A/B TNF RI TNF RII HLA: human leukocyte antigen; TLR: Toll-like receptor; TNF: tumor necrosis factor: RI: receptor I, RII: receptor II; MIC A-B: major 1; TSG101: tumor susceptibility gene 101.
Zymosan, a beta-glucan and mannan-rich ligand binds to Dectin-1 [139], and Dectin-1 interacts with the tetraspanin molecule CD37. Dectin-1 binds to Saccharomyces, Candida, Pneumocystis, Coccidiodes, Penicillium, and Aspergillus, but not Cryptococcus fungal species, leading to activation of Dectin-1+ cells and elimination of fungal pathogens by activating inflammatory responses, such as TNF-alpha, CDCL1, IL-1beta, GM-CSF, and IL-6, by the presence of an ITAM in its cytoplasmic tail [135].
Trubion retains the right to develop and commercialize, on its own or with others, product candidates directed to all targets not included within the agreement, including CD37.
Finally, the protocol was able to distinguish the mutant alleles in five DNA samples from other population groups with mutations (previously characterized) not found in the Greek population but within the gene regions covered by the mutation detection probes designed in this protocol (IVSI-1G [right arrow] T, IVSI-5G [right arrow] C, IVSI-116T [right arrow] G, Cd37 TGG [right arrow] TGA, and Cd41/42 -TCTT).
Gene expression of T-cell markers such as CD3 a subunit of the T-cell receptor, was decreased in spleen, whereas in blood, HCB decreased gene expression for CD3 and CD37, the latter being a B-cell marker.
Betalutin is selective for CD37, a novel therapeutic target protein that is highly expressed on the surface of B-cell non-Hodgkin's lymphoma (NHL) cells.
Betalutin is selective for CD37, which is highly expressed on the surface of B-cell non-Hodgkin's lymphoma (NHL) cells.
CD37 is highly expressed in B-cell non-Hodgkin's lymphoma, representing a novel therapeutic target.