platelet glycoprotein IV deficiency

(redirected from CD36 deficiency)

platelet glycoprotein IV deficiency

An inherited haematologic disorder (OMIM:608404) characterised by a complete type I (complete CD36 deficiency) phenotype, in which platelets and monocytes/macrophages have no CD36, and type II (partial CD36 deficiency) phenotype, in which there is no surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.

Molecular pathology
Defects in CD36, which encodes the fourth major platelet surface glycoprotein (PGIV), a receptor for thrombospondin, cause platelet glycoprotein deficiency.
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References in periodicals archive ?
Matsuzawa, "CD36 deficiency associated with insulin resistance," Lancet, vol.
Yasue et al., "Absent myocardial iodine-123-BMIPP uptake and platelet/monocyte CD36 deficiency," Journal of Nuclear Medicine, vol.
"If human diabetes is shown to be due, even in some cases, to CD36 deficiency, then it gives us a handle on a primary cause of the disease," says Aitman.