CD36


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CD36

a transmembrane protein present on monocytes, platelets, megakaryocytes, the umbilical vein, small-vessel endothelium, reticulocytes, and mammary epithelium that may be involved in signal transduction; expressed in myeloproliferative disorders.

CD36

A gene on chromosome 7q11.2 that encodes the fourth major platelet surface glycoprotein, which is a receptor for thrombospondin. It is acts as a cell adhesion molecule, binding to collagen, thrombospondin, anionic phospholipids, oxidised LDL, long-chain fatty acids and Plasmodium falciparum-parasitised erythrocytes.
 
Molecular pathology
Defects in CD36 cause platelet glycoprotein deficiency; genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7.
References in periodicals archive ?
Other than discrimination between lipoproteins, TLR2 has the ability to act together with co-receptor (CD36) by working with the heterodimer to mediate the sensing of some but not all TLR2 agonists which induces internalization.
Entre ellos, se caracterizo inicialmente a los de los tipos SRA y CD36 como receptores de macrofagos para lipoproteinas modificadas (32).
A recent experimental study indicated that CT-1 accelerates the development of atherosclerotic lesions by stimulating the inflammasome, foam cell formation associated with CD36 and acyl-CoA: cholesterol acyltransferase-1 upregulation in macrophages, and migration, proliferation, and collagen-1 production in vascular smooth muscle cells [24].
(2012) Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process.
However, recent research in animals suggests that finding ways to limit an immune system protein called CD36, which appears to promote inflammation and the generation of cell-damaging free radicals, might one day result in effective therapies for CAA.
The LBE treated cells showed a specific increase in expression of PPAR target gene expression, including fatty acid binding protein 4, fatty acid transport protein 4, CD36 molecule, pyruvate dehydrogenase kinase 4, liver X receptor alpha and lipogenic stearoyl-CoA desaturase.
falciparum infection, cytoadhesion of the parasitized blood cells to the endothelial cells is due to the interactions between PfEMP1 encoded by the var gene family and defined host receptors on endothelial cells like cluster of differentiation-36 (CD36), intercelluar adhesion molecule-1 (ICAM-1), and chondroitin sulfate A (CSA).
TSP-1 bir matriseluler protein ve antianjiyogenik faktor olup transmembran reseptor CD36 aktivasyonu ile apoptozisi gerceklestirmektedir.
CD36 ELISA Assay: An ELISA assay specific to mouse CD36 fatty acid transport protein was purchased from Abcam (Cambridge, MA) and performed in accordance with manufacturer's protocols.
Recientemente, estudios realizados en ratones han demostrado que FAI fosforila/desfosforila el transportador intestinal de acidos grasos CD36, siendo el mecanismo de desfosforilacion el que favorece la capacidad de absorcion de acidos grasos libres (AGL) (27).
Platelet reactivity for different disease pathogenesis is widely dependent upon some biologically active markers like CD36, CD41, CD42a, CD42b, and CD61.
Henson, "CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor ([alpha](V)[beta]3)," The Journal of Immunology, vol.