CD36


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CD36

a transmembrane protein present on monocytes, platelets, megakaryocytes, the umbilical vein, small-vessel endothelium, reticulocytes, and mammary epithelium that may be involved in signal transduction; expressed in myeloproliferative disorders.

CD36

A gene on chromosome 7q11.2 that encodes the fourth major platelet surface glycoprotein, which is a receptor for thrombospondin. It is acts as a cell adhesion molecule, binding to collagen, thrombospondin, anionic phospholipids, oxidised LDL, long-chain fatty acids and Plasmodium falciparum-parasitised erythrocytes.
 
Molecular pathology
Defects in CD36 cause platelet glycoprotein deficiency; genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7.
References in periodicals archive ?
CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure.
There was also an increase in the gene expression of the CD36 scavenger receptor in the grafted hearts that was, however, more discrete, at two- (controls) to four-fold (LDE-MTX treated) increase range (Figure 2I-K).
Plasmodi falciparum malaria and the immunogenetics of ABO, HLA, and CD36 (platelet glycoprotein IV).
Immunohistochemistry revealed that CD36 was localized to the macrophage-rich area of intima within atherosclerotic lesion.
Stimulation of CD36 and the key effector of reverse cholesterol transport ATP binding cassette A1 in monocytoid cells by niacin.
Asociacion del polimorfismo T188G en el gen del transportador lipidito CD36 con diabetes mellitus tipo 2 en mestizos mexicanos del occidente de Mexico.
HIV-1 Nef impairs key functional activities in human macrophages through CD36 downregulation.
IAPP puede ser internalizado al citosol de los macrofagos por la proteina de membrana CD36 y adentro ser convertido a su forma amiloide, lo cual altera el fagolisosoma y activa el inflamosoma NLRP3 debido a la liberacion de catepsinas.
falciparum GPI-induced M[PHI] activation is typically CD36 dependent transmits through MAPK, namely extracellular signal regulated kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) pathways as well as through the Nuclear factor-kappa B (NF-[kappa]B).
Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells," Medical Gas Research, vol.
Several vascular receptors are identified, of which intracellular adhesion molecule1 is probably the most important in the brain and CD36 in most other organs.