ERBB2

(redirected from CD340)

ERBB2

A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and enhancing kinase-mediated activation of downstream signalling pathways (e.g., those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase).

Molecular pathology
ERBB2 amplification and overexpression commonly occurs in breast and ovarian cancers.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Human epidermal growth factor receptor 2 (HER2), also known as CD340, is a member of a big receptor family, encoded by a protooncogene whose alterations (almost amplification and overexpression) are common not only in breast and gastric, but also in urothelial cancer.
The HUGO Nomenclature Committee (HGNC) has designated ERBB2 as the approved symbol and CD340, HER-2, HER2, and NEU as synonyms (http://www genenames.org/cgi-bin/gene_symbol_report?hgnc_id^3430; accessed June 25, 2014).
What is more, BM-MSCs have been shown to be positive for CD22, CD51, CD64a, CD340, and CD349, comparing to ASCs [94].
Human epidermal growth factor receptor 2 (Her2/neu, also referred to as ERBB2, CD340, or p185, encoded by gene ERBB2) is a member of the epidermal growth factor receptor family (ErbB protein family).
(78) Overexpression of the HER2/neu (ERBB2, CD340) receptor tyrosine kinase was capable of rescuing LNCaP cells from the antiproliferative effect of androgen deprivation and also shortened the latency period for tumor formation in castrated mice with severe combined immunodeficiency by 50%.