CD317

CD317

A 29–33-kD type II transmembrane glycoprotein, which is up-regulated on most cell types after stimulation with type I interferons and interferon-gamma. It blocks release of HIV-1 and other retroviruses from infected cells, and is the natural ligand of ILT7.

Normal expression
Synovial cells, bone marrow stem cell lines, type I IFN-producing cells; highly expressed on differentiated dendritic cells.

Abnormal expression
Myeloma, renal cell carcinoma, melanoma.
References in periodicals archive ?
report their investigation of bone marrow stromal antigen 2 (BST2; also known as CD317, tetherin, and HM1.24) as a plasma biomarker in 152 patients with CRC.
Abbreviations, CD numeration, and alternate names: DEC-205 (CD205), B220 (CD45R), PDCA-1 (plasmacytoid DC Ag-1; CD317; Bst2), Siglec H (Sialic acid-binding immunoglobulin-like lectin H), Langerin (CD207), CD141 (BDCA-3), CD1c (BDCA-1), and CD303 (BDCA-2).
John Guatelli, at the University of California, San Diego, also experimented with the CD317 protein which appears to play this tethering or attaching role (Abstract #104a).