CLEC4C

(redirected from CD303)

CLEC4C

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain protein involved in antigen capture, targeting ligands to peptide-loading compartments for presentation to T-cells. CLEC4C may downregulate IFN-alpha/beta expression in plasmacytoid dendritic cells; it may also act as a signalling receptor, activating protein-tyrosine kinases and mobilising intracellular calcium.
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showed that CD123 and CD303 (BDCA2) were expressed in 11 out of 123 (9%) and 4 out of 124 (3%) myeloid leukemia cutis (LC) cases, respectively.
BPDCN; BDCA2/ CD303, blood dendritic cell antigen 2; TCL1, T-cell leukemia/lymphoma 1; CD2AP CD2-associated protein; CLA, cutaneous lymphocyte antigen; BCL11A, B-cell lymphoma/leukemia 11A; MPO, myeloperoxidase; TdT, terminal deoxynucleotidyl transferase; EBER, EBV-encoded nuclear RNA.
Blastic plasmacytoid dendritic cell neoplasm: report of a case presenting with lung and central nervous system involvement and review of the literature
They also express CD303 (blood dendritic cell antigen 2, BDCA2), cutaneous lymphocyte-associated antigen (CLA), granzyme B, and TCL1.
Blastic Plasmacytoid Dendritic Cell Neoplasm: A Clinicopathologic Review
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